“…A more accurate and reliable optimization conclusion can be obtained with a fewer number of experiments after using an orthogonal design, and it allows for performing both range analysis (R) and analysis of variance (ANOVA) to evaluate test results. There is growing interest in the use of orthogonal design methods for optimization in various fields [ 28 , 51 , 52 , 53 , 54 , 55 ]. Therefore, a university teaching-office building was researched in this paper through orthogonal design and numerical simulation (EnergyPlus) to explore the adaptability (including the optimal parameters and influence degree of each factor of the envelope and the significance levels) of the energy-saving factor of the building envelopes under different climates, which aims to provide the optimal solution for the renovation of university teaching-office building envelopes under different climatic conditions in China to achieve maximum energy-saving building operations.…”