A Total Synthesis of (±)-Vincamine and (±) -Eburnamonine

Abstract

<jats:title>Abstract</jats:title><jats:p> A synthesis of vincamine (1) and eburnamo-nine (2) is reported which involves a new route to the key intermediate (8).</jats:p>

Homologation of ketones into carboxylic acids

“…pyrrole, Et 2 NH, i-Pr 2 NH) also gave good yields of the enamines 109. 99 Representative hydrolysis methods of enamine 109 to homologated aldehyde 110 include, aqueous HCl, 133 aqueous AcOH, 134 and aqueous oxalic acid. 135 A selection of substrates that are transformed is shown in Table 11.…”