A Toxic Lipid from the Surface of Corynebacterium ovis

Carne, H. R.; Wickham, Nancy; Kater, Joan C.

doi:10.1038/178701a0

Cited by 33 publications

(17 citation statements)

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“…The latter is considered to have more in¯uence on the production of chronic abscessation in sheep than the total lipid content (Muckle and Gyles, 1983). Injection of these lipids intradermally in guinea pigs led to evolution of local toxic action within 24 h without development of delayed systemic toxicity, which con®rms the local toxic character of lipids (Carne et al, 1956). Anyhow, cell wall lipids of Corynebacteria have been identi®ed as possible virulence factor of the organism, but their exact role in disease and immunity is not well de®ned (Muckle et al, 1992).…”

Section: Selimmentioning

confidence: 97%

“…Leukocytes are especially vulnerable with no delayed systemic toxic effects. Intraperitoneal injection of cord‐like factor in mice caused death in 2–3 weeks with the appearance of haemorrhages in lungs (Carne et al., 1956). It has been suggested that the cell wall lipids could be involved in the formation of local abscesses (Holstad et al., 1989).…”

Section: Microbiologymentioning

confidence: 99%

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Oedematous Skin Disease of Buffalo in Egypt

Selim

2001

Journal of Veterinary Medicine, Series B

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This review covers a historical view and etiology of oedematous skin disease which affects buffalo in Egypt, the microbiology of Corynebacterium pseudotuberculosis causing the disease: its virulence; clinical signs; mechanism of pathogenesis; histopathology; mode of transmission; immunological aspects; treatment and control. It is concluded that C. pseudotuberculosis serotype II is the main cause of OSD and exotoxin phospholipase D and its lipid contents of the cell wall are the major causes of pathogenesis. After declaring the role of Hippobosca equina in transmission of the causative agent among buffaloes, control of OSD is now available.

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Section: Selimmentioning

confidence: 97%

Section: Microbiologymentioning

confidence: 99%

Oedematous Skin Disease of Buffalo in Egypt

Selim

2001

Journal of Veterinary Medicine, Series B

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“…The surface lipids of C. pseudotuberculosis have long been described as major factors contributing to its pathogenesis [18,47,48,58]. The toxicity of the extracted lipid material has been demonstrated by the induction of hemorrhagic necrosis following intradermal injection in guinea pigs [58].…”

Section: Toxic Cell-wall Lipidsmentioning

confidence: 99%

Corynebacterium pseudotuberculosis: microbiology, biochemical properties, pathogenesis and molecular studies of virulence

et al. 2006

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-Corynebacterium pseudotuberculosis is the etiological agent of caseous lymphadenitis (CLA), a common disease in small ruminant populations throughout the world. Once established, this disease is difficult to eradicate because drug therapy is not effective and because the clinical detection of infected animals is of limited efficiency. We reviewed the microbiological, biochemical and taxonomic features of C. pseudotuberculosis, general aspects of infection, the main virulence determinants and currently available commercial vaccines. We also examined the current molecular strategies for the study of virulence in C. pseudotuberculosis, including the latest research on the identification of novel virulence factors and genes, which will help us to better understand the biology of this microorganism. This knowledge may also contribute to the development of improved CLA vaccines, including subunit and DNA-based types, as well as to improve the diagnosis, treatment and control of this disease.

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“…ht5morragique. En outre, in vitro, ces lipides (adsorb& sur des particules de charbon) sont toxiques pour les leucocytes qui les ont phagocytes [2]. Plus recernment, Jolly [3] a observe qu'une souche virulente de C. ovis contient plus de lipides extractibles par 1'Bther de petrole qu'une souche attenuee ; cependant, la souche attenuee conserve la capacit6 de synthkse de lipides toxiques.…”

unclassified

Sur quelques constituants lipidiques de Corynebacterium ovis

Lacave¹,

Asselineau²,

Toubiana³

1967

European Journal of Biochemistry

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The lipids of Corynebacterium ovis (strain B1/50) were successively extracted by petroleumether, ethanol-ether (1 : I, v/v) and chloroform.The bulk of the petroleum-ether extract consists mainly of sodium corynomycolate together with sodium salts of CI4, C, , and C,, fatty acids. Some triglycerides and free fatty acids were also detected. Isolated from the ethanol-ether extract were : hydrocarbons, palmitone, free corynomycolic acid, a small amount of free corynomycolenic acid and a peptidolipid fraction. The phospholipid fraction contains a mixture of closely related compounds, having about 3.5 Ol0 P. By hydrolysis, they are split into lipid components (50-70°/, of the initial products; mixtures of C,, and C, , fatty acids and corynomycolic acid), and water soluble components (glycerol, glycerophosphoric acid, inositol, arabinose, and small amounts of amino acids).Complex substances, soluble in ether, having a high content of phosphorus (3.2 to 4.5 o/o) were isolated from 6he chloroform extract. All of them contain glycerol, along with ethanolamine and sugars (glucose, galactose, arabinose, and a fast moving unidentified sugar) in one case, and with amino acids (chemically bound) in two other cases. Moreover, one third of the chloroform extract is made of a fraction (10.8 Ol0 N and 1.3 P) insoluble in ether, which gives, by hydrolysis, 1901, of lipid components and a polypeptide containing all the usual amino acids; the structure of this last fraction is discussed.

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A Toxic Lipid from the Surface of Corynebacterium ovis

Cited by 33 publications

References 1 publication

Oedematous Skin Disease of Buffalo in Egypt

Oedematous Skin Disease of Buffalo in Egypt

Corynebacterium pseudotuberculosis: microbiology, biochemical properties, pathogenesis and molecular studies of virulence

Sur quelques constituants lipidiques de Corynebacterium ovis

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