A toxic reagent-free method for normal-phase matrix solid-phase dispersion extraction and reversed-phase liquid chromatographic determination of aldrin, dieldrin, and DDTs in animal fats

Abstract

A method for the determination of aldrin, dieldrin, DDT, DDE, and DDD contamination in animal fats (beef tallow, lard, and chicken fat) without using toxic reagents is developed, that uses high-performance liquid chromatography after the sample has been prepared by matrix solid-phase dispersion (MSPD) with acidic alumina oxide. A reversed-phase C(1)-silica column with a mobile phase of 50% (v/v) ethanol solution (in water) and a photo-diode array detector were used for the determination. Average recoveries of the target compounds (0.2-5.0 microg g(-1)) ranged from 84-98%, with coefficients of variation of <5%. The limits of quantitation were </=0.16 microg g(-1 )for AD, </=0.10 microg g(-1) for DD, </=0.06 microg g(-1) for DDT, </=0.07 microg g(-1) for DDE, and </=0.05 microg g(-1 )for DDD. No toxic reagents were used at all.

Determination of Parabens and Triclosan in Indoor Dust Using Matrix Solid-Phase Dispersion and Gas Chromatography with Tandem Mass Spectrometry

“…Recently, some authors have described the possibility of using inert materials, e.g., sand and diatomaceous earth, instead of functionalized silica sorbents as sample dispersants. − As a result, the cost of MSPD extractions is reduced considerably. In order to explore the suitability of this approach for the determination of parabens and triclosan in dust, a pool of several nonspiked samples was prepared.…”

“…Organic compounds contained in the sample are dissolved and dispersed into the silica-bonded apolar phases . In further works, normal-phase sorbents and relatively inert materials, such as sand and diatomaceous earth, have been employed also as dispersants. − Obviously, in this case, interactions between sample components and dispersant take place only through adsorption processes.…”

Supercritical fluid extraction followed by nanostructured supramolecular solvent extraction for extraction of levonorgestrel and megestrol from whole blood samples

“…A c c e p t e d M a n u s c r i p t However, MSPD procedure generally needs longer analytical time and its limit of detection (LOD) is limited [21]. Also, owing to the fact that sorbents are nonselective, further purification of the extracts is often still required to remove coextractants before further analysis.…”

Achievements and Challenges of Matrix Solid-Phase Dispersion Usage in the Extraction of Plants and Food Samples

“…Its simplicity of use and its flexibility contribute to it being more often chosen than other methods. Given the above, this method is one of the most commonly used in testing laboratories [1][2][3][4][5]. The interest in MSPD is not decreasing, as evidenced by the possibilities of its practical use and the number of available articles (Figure 1).…”