A toxicological investigation of a celery seed extract having anti-inflammatory activity

Powanda, Michael C.; Rainsford, K. D.

doi:10.1007/s10787-010-0049-1

Cited by 25 publications

(16 citation statements)

References 20 publications

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“…In the chronic model of pain and inflammation in the rat previously described, 1,500 mg/kg per day was shown to be as effective as either naproxen (30 mg/kg) or ibuprofen (100 mg/kg), but with a lag time of about 4-5 days before a similar degree of efficacy was observed (Powanda and Rainsford 2010). Using the same body surface area correction factor used above, this would translate into a human dose of 243 mg/kg or 17.03 g/day for a 70 kg person.…”

Section: Safety Of Cse (Beagle International Pty Ltd)mentioning

confidence: 84%

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Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Powanda¹,

Whitehouse

Rainsford

2015

Progress in Drug Research

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Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis. CSE can also reduce existing inflammation in rats. CSE has also been shown to provide analgesia in two model systems. CSE, in addition to acting as an analgesic and inflammatory agent, has been shown to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation. The CSE was fractionated by organic solvent extractions, then subjected to column chromatography followed by HPLC and was characterized by mass spectrometry. This yielded a purified component that had specific inhibitory effects on Helicobacter pylori but was not active against Campylobacter jejuni or Escherichia coli. Additionally, toxicology studies did not reveal any clear signs of toxicity at doses relevant to human use. Also, unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems and thus is less likely to alter the metabolism of drugs the individual may be taking. CSE may be a prototype of a natural product that can be used therapeutically to treat arthritis and other inflammatory diseases.

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Section: Safety Of Cse (Beagle International Pty Ltd)mentioning

confidence: 84%

“…A toxicity study was undertaken in 18 adult male and 18 adult female Sprague Dawley rats (Powanda and Rainsford 2010). These were randomly assigned to three treatment groups of six rats/sex/group and were administered doses of A-CSE of 0, 150, or 5,000 mg/kg per day.…”

Section: Safety Of Cse (Beagle International Pty Ltd)mentioning

confidence: 99%

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Powanda¹,

Whitehouse

Rainsford

2015

Progress in Drug Research

View full text Add to dashboard Cite

show abstract

“…In the chronic model of pain and inflammation in the rat previously described, 1,500 mg/kg per day was shown to be as effective as either naproxen (30 mg/kg) or ibuprofen (100 mg/kg), but with a lag time of about 4-5 days before a similar degree of efficacy was observed (Powanda and Rainsford 2010). Using the same body surface area correction factor used above, this would translate into a human The CSE supplied by Beagle International Pty Ltd (Nerang, QLD, Australia) also was tested in 64 ligand binding and enzyme interaction assays, as part of the General Side Effect Profile array, as well as in the glucocorticoid assay.…”

Section: Safety Of Cse (Beagle International Pty Ltd)mentioning

confidence: 90%

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

2015

Progress in Drug Research

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“…According to the previous researches, no toxicity has been reported in the administration of different doses of celery seeds. In a study by Powanda et al (2010), no toxicity was seen after 28 days administration of 150 and 5000 mg/kg per day of celery seeds. 31 Also, Al-Howiriny et al did not observe any toxic symptoms or mortality in IP administration of doses 250 and 500 mg/kg per day.…”

Section: Figmentioning

confidence: 95%

“…In a study by Powanda et al (2010), no toxicity was seen after 28 days administration of 150 and 5000 mg/kg per day of celery seeds. 31 Also, Al-Howiriny et al did not observe any toxic symptoms or mortality in IP administration of doses 250 and 500 mg/kg per day. 32 Therefore, the present work provides evidence of a hypotensive effect of celery seeds, which appears to be attributable to the action of some hydrophobic constituents, for example, NBP in this plant.…”

Section: Figmentioning

confidence: 95%

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Moghadam

Imenshahidi

Mohajeri

2013

Journal of Medicinal Food

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This study investigated the effects of different celery (Apium graveolens) seed extracts on blood pressure (BP) in normotensive and deoxycorticosterone acetate-induced hypertensive rats. The hexanic, methanolic, and aqueous-ethanolic extracts were administered intraperitoneally and their effects on BP and heart rate (HR) were evaluated in comparison with spirnolactone as a diuretic and positive control. Also, the amount of n-butylphthalide (NBP), as an antihypertensive constituent, in each extract was determined by HPLC. The results indicated that all extracts decreased BP and increased the HR in hypertensive rats, but had no effect on normotensive rats. The data showed that administration of 300 mg/kg of hexanic, methanolic, and aqueous-ethanolic (20/80, v/v) extracts of the celery seed caused 38, 24, and 23 mmHg reduction in BP and 60, 25, and 27 beats per minute increase in the HR, respectively. Also, the HPLC analysis data revealed that the content of NBP in the hexanic extract was 3.7 and 4 times greater than methanolic and aqueous-ethanolic extracts. It can be concluded that celery seed extracts have antihypertensive properties, which appears to be attributable to the actions of its active hydrophobic constitutes such as NBP and can be considered as an antihypertensive agent in chronic treatment of elevated BP.

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A toxicological investigation of a celery seed extract having anti-inflammatory activity

Abstract: These results suggest that there are no toxicologically significant sub-chronic effects of oral A-CSE in rats. The no adverse effect level for systemic toxicity would appear to be 5,000 mg/kg per day.

Cited by 25 publications

References 20 publications

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

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