A toxicology evaluation of postnatal maternal exposure to cesium

Messiha, F.S.

doi:10.1016/0031-9384(89)90327-2

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…They concluded that the radioac ti vit y in milk was high enough to represe nt a danger afte r ingestio n by humans. Maternal exposure to Cs during lactation in mice has been shown to affect body weight and reduce brain weight of the offspring (Messiha 1989). Repeated treatment with AFCF was shown to significantly decrease milk transport of cesi um in the prese nt study with 40%.…”

Section: Rmentioning

confidence: 93%

Transfer of ¹³⁷Cesium via Rat Milk: Reduction with Ammonium Ferric Hexacyanoferrate

Sundberg

Oskarsson

1991

Pharmacology & Toxicology

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Dose-dependent transfer of 137cesium (137Cs) into milk and uptake in suckling rats after a three-day nursing period was studied. On lactation day 9, the dams were administered a single oral dose of cesium, labeled with 137cesium chloride, in six doses from 0.4 to 19.7 micrograms Cs/kg. In addition, one group of rats was given ammonium-ferric(III)-hexacyanoferrate(II) (AFCF). There was a linear dose-dependent relationship between Cs levels in plasma and milk, as well as in whole blood and milk. The Cs milk/plasma ratios were 7 at 24 hr and 6 at 72 hr after Cs administration. Cesium concentration in milk was linearly correlated with tissue levels in suckling offspring at 72 hr. Concentration ratios of cesium in tissues between pups and their lactating dams ranged from 0.5 to 1.2. Repeated treatment with AFCF (50 mg) given orally at 24, 30, 48 and 54 hr after a single administration of 137Cs, resulted in significantly decreased Cs levels in dam's kidney, liver, lung, erythrocytes and blood at 72 hr. In addition, Cs level in milk was decreased by 40% in rats treated with AFCF. However, no effects of AFCF on Cs levels in tissues of suckling pups were observed.

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Section: Rmentioning

confidence: 93%

Transfer of ¹³⁷Cesium via Rat Milk: Reduction with Ammonium Ferric Hexacyanoferrate

Sundberg

Oskarsson

1991

Pharmacology & Toxicology

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Developmental toxicity of cesium in the mouse

Messiha

1994

General Pharmacology: The Vascular System

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A toxicology evaluation of postnatal maternal exposure to cesium

Cited by 2 publications

References 18 publications

Transfer of ¹³⁷Cesium via Rat Milk: Reduction with Ammonium Ferric Hexacyanoferrate

Transfer of ¹³⁷Cesium via Rat Milk: Reduction with Ammonium Ferric Hexacyanoferrate

Developmental toxicity of cesium in the mouse

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A toxicology evaluation of postnatal maternal exposure to cesium

Cited by 2 publications

References 18 publications

Transfer of 137Cesium via Rat Milk: Reduction with Ammonium Ferric Hexacyanoferrate

Transfer of 137Cesium via Rat Milk: Reduction with Ammonium Ferric Hexacyanoferrate

Developmental toxicity of cesium in the mouse

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Transfer of ¹³⁷Cesium via Rat Milk: Reduction with Ammonium Ferric Hexacyanoferrate

Transfer of ¹³⁷Cesium via Rat Milk: Reduction with Ammonium Ferric Hexacyanoferrate