1989
DOI: 10.1084/jem.170.3.777
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A trans-acting major histocompatibility complex-linked gene whose alleles determine gain and loss changes in the antigenic structure of a classical class I molecule.

Abstract: The RT1.A locus of the rat MHC encodes the H chain of the single classical class I molecule of this species. One of the alleles of this polymorphic locus, RT1.Aa, is present in several laboratory inbred, congenic, and MHC recombinant rat strains. Studies of the RT1.Aa class I molecule from a number of these strains as a target for CTL show that its antigenicity, both as an alloantigen and a restricting element, is subject to gain and loss alterations by the action of a gene mapping in the MHC to the right of R… Show more

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Cited by 91 publications
(36 citation statements)
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“…Two versions of the heterodimeric TAP, TAP-A and TAP-B, are expressed in the rat due to the existence of two alleles of TAP2 in this species (61,62). The specificity for peptide transport differs between TAP-A and TAP-B, and only one or the other TAP2 allele is expressed in each inbred rat strain (63).…”
Section: Discussionmentioning
confidence: 99%
“…Two versions of the heterodimeric TAP, TAP-A and TAP-B, are expressed in the rat due to the existence of two alleles of TAP2 in this species (61,62). The specificity for peptide transport differs between TAP-A and TAP-B, and only one or the other TAP2 allele is expressed in each inbred rat strain (63).…”
Section: Discussionmentioning
confidence: 99%
“…While screening cosmid clones spanning this area, they came across two homologous genes encoding proteins with sequence similarity to a large family of transport proteins (1). Jonathan Howard and Geoffrey Butcher's group had previously identified a locus in the rat MHC, termed the class I modification (cim) locus, that modified the specificity of class I-restricted Ag presentation (10). Using an overlapping set of cosmid clones covering the cim locus, they identified two expressed genes with homology to the mouse genes identified by Monaco's group (2).…”
Section: Luc Van Kaermentioning
confidence: 99%
“…I), alterando su reconocimiento por células T aloreactivas y bloqueando su capacidad de presentar antigenos de histocompatibilidad menores a los CTL. La ubicación de este gen fue la región clase II del MHC de la rata y se le denominó cim" (22) En ratones y humanos el fenómeno se descubrió mediante el análisis de líneas celulares que tenían defectos en la presentación de antígenos exógenos a los CTL, las cuales se inducían tratándolas con sulfonato etil metano o con radiaciones sucesivas, y se seleccionaban con anticuerpos anti-MHC (7,23), tabla 1. Dos de los genes relacionados con estos defectos se localizaron también en la región clase II del ratón y del humano, y su denominación se hizo inicialmente por cada investigador.…”
Section: Procesamiento De Antígenos Citoplasmáticosunclassified
“…La transfección con el cDNA del gen Y3 (ver tabla2) en células mutantes humanas, mostróque en algunas se producía un aumento en los niveles de moléculas MHC clase I en la membrana y además se corregía la capacidad de presentar péptidos a los CTL; en cambio en otras la transfección no corregia el problema, sugiriendo que había más genes implicados y que lafalla en la corrección del defecto se debía a una deleción homocigota, que además involucrabaotros genes. Esto último sugirió la existencia del gen Y1 (2,22). TABLA …”
Section: Procesamiento De Antígenos Citoplasmáticosunclassified