2024
DOI: 10.1101/2024.01.25.577217
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A transcription network underlies the dual genomic coordination of mitochondrial biogenesis

Fan Zhang,
Annie Lee,
Anna Freitas
et al.

Abstract: Mitochondrial genome encodes handful genes of respiratory chain complexes, whereas all the remaining mitochondrial proteins are encoded on the nuclear genome. However, the mechanisms coordinating these two genomes to control mitochondrial biogenesis remain largely unknown. To identify transcription circuits involved in these processes, we performed a candidate RNAi screen in developing eyes that had reduced mitochondrial DNA contents. We reasoned that impaired mitochondrial biogenesis would synergistically int… Show more

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“…2c). As intact seminal vesicles are impermeable to DAPI, we imaged an endogenously tagged TFAM reporter, TFAM-mNeonGreen 20 , which marks mitochondrial nucleoids (Extended Data Fig. 2d, e), to assess mtDNA in mature sperm.…”
Section: Mainmentioning
confidence: 99%
“…2c). As intact seminal vesicles are impermeable to DAPI, we imaged an endogenously tagged TFAM reporter, TFAM-mNeonGreen 20 , which marks mitochondrial nucleoids (Extended Data Fig. 2d, e), to assess mtDNA in mature sperm.…”
Section: Mainmentioning
confidence: 99%