A transcultural cognitive marker of Alzheimer's Disease

Sala, Sergio Della; Козлова, И. А.; Stamate, Andreea; Parra, Mario A.

doi:10.1002/gps.4610

Cited by 34 publications

(48 citation statements)

References 67 publications

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“…Without titration and with high memory load, (Koppara et al, 2015) reported that such selectivity disappeared in MCI samples. However, when memory load is low, the selectivity of binding is restored in these MCI people and mirrors that found in patients with AD dementia (Sergio Della Sala et al, 2017).…”

Section: Why Dissecting Memory Binding Impairments Is Important?supporting

confidence: 65%

“…Interestingly, a subgroup of controls (n=7) showed performance below a recently reported cut-off (Sergio Della Sala et al, 2017) despite an intact neuropsychological background.…”

Section: Why Dissecting Memory Binding Impairments Is Important?mentioning

confidence: 73%

“…The above described VSTMBT has been used extensively in experimental studies involving different populations with AD dementia or at risk of such dementia. More clinically friendly versions of the task (i.e., shorter version on PC or flashcard versions; see (Della Sala, et al, 2017)) have been recently developed and validated.…”

Section: The Visual Short-term Memory Binding Test (Vstmbt)mentioning

confidence: 99%

“…Previous studies have manipulated memory load by presenting patients and controls with a different number of to-be-remembered items (Sergio Della Sala, Data, Stamate, & Parra, 2017;S. Della Sala et al, 2012;Parra et al, 2009;Parra, Abrahams, Logie, Mendez, et al, 2010;Parra et al, 2011).…”

mentioning

confidence: 99%

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Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test

Parra

Calia

Garcia

et al. 2019

Archives of Gerontology and Geriatrics

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Alzheimer's disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). We compared data from two studies on temporary binding which assessed people with MCI and controls using different memory loads (2 or 3 items). Selective binding impairments were found in MCI, but relative to controls, such selectivity was contingent upon memory load (i.e., present with 2 items). Further analysis with MCI people who tested positive to neuroimaging biomarkers (i.e., hippocampal atrophy) confirmed that this specific binding impairments are a feature of prodromal AD. The temporary binding task has been recently suggested by consensus papers as a potential screening tool for AD. The results presented here inform on task properties that can maximise the reliability of this new assessment tool for the detection of memory impairments in prodromal cases of AD.

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Section: Why Dissecting Memory Binding Impairments Is Important?supporting

confidence: 65%

“…Interestingly, a subgroup of controls (n=7) showed performance below a recently reported cut-off (Sergio Della Sala et al, 2017) despite an intact neuropsychological background.…”

Section: Why Dissecting Memory Binding Impairments Is Important?mentioning

confidence: 73%

Section: The Visual Short-term Memory Binding Test (Vstmbt)mentioning

confidence: 99%

mentioning

confidence: 99%

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Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test

Parra

Calia

Garcia

et al. 2019

Archives of Gerontology and Geriatrics

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“…A recent study has stressed on the cultural validity of the VSTM binding test (Della Sala et al, 2016). Here, we have shown that VSTM binding of features of everyday objects is preserved in older adults who have a low educational background.…”

Section: Discussionmentioning

confidence: 99%

Feature Binding of Common Everyday Items Is Not Affected by Age

Hoefeijzers

Hernández

Ríos

et al. 2017

Front. Aging Neurosci.

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There is a surge of studies confirming that old age spares the ability to bind in visual working memory (VWM) multiple features within singular object representations. Furthermore, it has been suggested that such ability may also be independent of the cultural background of the assessed individual. However, this evidence has been gathered with tasks that use arbitrary bindings of unfamiliar features. Whether age spares memory binding functions when the memoranda are features of everyday life objects remains less well explored. The present study investigated the influence of age, memory delay, and education, on conjunctive binding functions responsible for representing everyday items in VWM. We asked 32 healthy young and 41 healthy older adults to perform a memory binding task. During the task, participants saw visual arrays of objects, colours, or coloured objects presented for 6 s. Immediately after they were asked either to select the objects or the colours that were presented during the study display from larger sets of objects or colours, or to recombine them by selecting from such sets the objects and their corresponding colours. This procedure was repeated immediately after but this time providing a 30 s unfiled delay. We manipulated familiarity by presenting congruent and incongruent object-colour pairings. The results showed that the ability to bind intrinsic features in VWM does not decline with age even when these features belong to everyday items and form novel or well-known associations. Such preserved memory binding abilities held across memory delays. The impact of feature congruency on item-recognition appears to be greater in older than in younger adults. This suggests that long-term memory (LTM) supports binding functions carried out in VWM for familiar everyday items and older adults still benefit from this LTM support. We have expanded the evidence supporting the lack of age effects on VWM binding functions to new feature and object domains (i.e., everyday items). We have confirmed that education does not negatively impact on such ability at old age. Such results have important implications for the selection of culturally unbiased tests to screen for abnormal ageing trajectories.

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Profiles of cognitive impairment in the continuum from normal cognition to Alzheimer's clinical syndrome: Contributions of the short‐term memory binding tests

Cecchini

Foss

Tumas

et al. 2020

Int J Geriat Psychiatry

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Background: Short-term memory binding (STMB) tests assess conjunctive binding, in which participants should remember the integration of features, such as shapes (or objects) and colors, forming a unique representation in memory. In this study, we investigated two STMB paradigms: change detection (CD) and free recall (FR). Objective: To investigate the cognitive profile in the CD and FR tasks of three diagnostic groups: cognitively unimpaired (CU), mild cognitive impairment (MCI), and Alzheimer's clinical syndrome (ACS). In addition, we aimed to calculate and compare the accuracy of the CD and FR tasks to identify MCI and ACS. Methods: Participants were 24 CU, 24 MCI, and 37 ACS. The cognitive scores of the clinical groups were compared using analysis of variance (ANOVA) and receiver-operating characteristic (ROC) analyses were carried out to verify the accuracy of the STMB tasks. Results: In the CD task, CU was different from MCI and ACS (CU > MCI = ACS), while in the FR task all groups were different (CU > MCI > ACS). The ROC analyses showed an area under the curve (AUC) of 0.855 comparing CU with MCI for the CD task and 0.975 for the FR. The AUC comparing CU and ACS was 0.924 for the CD and 0.973 for the FR task. The FR task showed better accuracy to identify MCI patients, and the same accuracy to detect ACS. Conclusion: The present findings indicate that impairments in CD and FR of bound representations are features of the cognitive profiles of MCI and ACS patients.

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A transcultural cognitive marker of Alzheimer's Disease

Cited by 34 publications

References 67 publications

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test

Feature Binding of Common Everyday Items Is Not Affected by Age

Profiles of cognitive impairment in the continuum from normal cognition to Alzheimer's clinical syndrome: Contributions of the short‐term memory binding tests

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