2000
DOI: 10.1038/sj.leu.2401936
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A transient dephosphorylation of JAK1 and JAK2 characterises the early-phase response of murine erythroleukemia cells to the differentiation inducer hexamethylenebisacetamide

Abstract: Although dephosphorylation of tyrosine containing proteins is considered a necessary step in the induction of leukemia cell differentiation by hybrid polar compounds (HPC), the crucial actors in this step remain unknown. We present evidence that tyrosine phosphorylation of JAK1 and JAK2 is down-regulated in murine erythroleukemia cells (MELC) within the first 6 h of their exposure to the prototype of the HPC family, hexamethylenebisacetamide (HMBA), with full recovery at 14 h. Further evidence that the JAKs-ce… Show more

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Cited by 3 publications
(1 citation statement)
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“…The latter could be a threshold value, required for cell survival, by preventing cells from losing K + ions, a prerequisite to enter the apoptotic pathway. 55,56 Alternatively, such values could be apt to maintain, in a properly activated state, [57][58][59] those voltage-dependent proteins involved in cell signalling, as well as to control the appropriate Ca 2+ entry into the cells through voltage-dependent channels. 60 On the whole, based on data reported in this study, we propose to include K + channel encoding genes, in particular the herg gene, among novel molecular markers of hematological disorders that are involved in the regulation of hemopoietic cell proliferation.…”
Section: Discussionmentioning
confidence: 99%
“…The latter could be a threshold value, required for cell survival, by preventing cells from losing K + ions, a prerequisite to enter the apoptotic pathway. 55,56 Alternatively, such values could be apt to maintain, in a properly activated state, [57][58][59] those voltage-dependent proteins involved in cell signalling, as well as to control the appropriate Ca 2+ entry into the cells through voltage-dependent channels. 60 On the whole, based on data reported in this study, we propose to include K + channel encoding genes, in particular the herg gene, among novel molecular markers of hematological disorders that are involved in the regulation of hemopoietic cell proliferation.…”
Section: Discussionmentioning
confidence: 99%