A transient increase in renal clearance of phosphate in response to continuous infusion of salmon calcitonin in rats.

Koide, Yoshinobu; Kugai, Nobuo; Yamashita, Kamejiro; Shimazawa, Eiichiro; Ogata, Etsuro

doi:10.1507/endocrj1954.23.295

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…All of these surgical procedures were completed in about 30min. The rats were immediately infused at a rate of 3mI/h via the cannulated femoral vein with a solution composed of 5 or 10 mM-CaCI2, 5 mm-MgCl2, 20mM-NaCl, 2.5mM-KCI and 4% glucose (Koide et al, 1976). In addition, graded amounts of bovine parathyrin (trichloroacetic acid-treated powder, 218 U.S.P.…”

Section: Protocol Of Infusion Experimentsmentioning

confidence: 99%

Salmon calcitonin-induced stimulation of 1α,25-dihydroxycholecalciferol synthesis in rats involving a mechanism independent of adenosine 3′:5′-cyclic monophosphate

Horiuchi¹,

Takahashi²,

Matsumoto³

et al. 1979

Biochemical Journal

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The effect of natural salmon calcitonin on accumulation in plasma of 1 alpha,25-dihydroxy-[3H]cholecalciferol from 25-hydroxy[3H]cholecalciferol in vivo was investigated in vitamin D-deficient thyroparathyroidectomized rats into which graded doses of the hormone were continuously infused by use of a balance study system. A dose-dependent increase in plasma concentrations of 1 alpha,25-dihydroxy[3H]cholecalciferol was observed with calcitonin infusion for 6--30h at a rate greater than 20 M.R.C. m-units/h. Infusion of parathyrin or cyclic AMP produced a similar stimulation [Horiuchi, Suda, Takahashi, Shimazawa & Ogata (1977) Endocrinoly 101, 969--974], but the maximal effect of calcitonin was additive to that of either parathyrin or cyclic AMP. Furthermore concurrent infusion of theophylline (0.5 mumol/h) did not potentiate the effect of submaximal doses (3 and 20 M.R.C. m-units/h) of calcitonin. Plasma concentrations of calcium showed a decrease with calcitonin infusion for 30h, but those of Pi remained unchanged. These results strongly suggest that the rat kidney is endowed with a calcitonin-sensitive 1 alpha-hydroxylase system that is separate from the parathyrin/cyclic AMP system and is independent of changes in plasma Pi.

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Section: Protocol Of Infusion Experimentsmentioning

confidence: 99%

Salmon calcitonin-induced stimulation of 1α,25-dihydroxycholecalciferol synthesis in rats involving a mechanism independent of adenosine 3′:5′-cyclic monophosphate

Horiuchi¹,

Takahashi²,

Matsumoto³

et al. 1979

Biochemical Journal

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“…Food was withheld for 24 hours before experiment. The surgical method and the procedure of the perfusion balance study were as described in detail in a preceding report (Koide et al 1976). In short, under anesthesia with hexobarbital a heparinized cannula was inserted into the left femoral vein for infusion of a nitrition solution, and a catheter was applied to the urinary bladder for hourly urine sampling with a fraction collector.…”

Section: Methodsmentioning

confidence: 99%

“…Urinary and serum specimens were stored under refrigeration (-20 °C). The measurement of urinary and serum electrolytes and creatinine was performed as described in the preceding report (Koide et al 1976). In case of phosphate, the results are presented as the amount of phosphorus.…”

Section: Methodsmentioning

confidence: 99%

Diurnal Changes in Calcium and Phosphate Metabolism in Rats

Kishikawa¹,

Takahashi²,

Shimazawa³

et al. 1980

Horm Metab Res

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Diurnal changes in the metabolism of calcium and phosphate were studied in fasted conscious rats by use of a perfusion balance study method. On a light dark 12:12 h schedule and on a constant iv load of calcium among other nutrients, the animals exhibited a diurnal rhythm in which urinary excretion of calcium was low in the night and high in the day. This was accompanied by a reciprocal change in phosphate balance (high excretion in the night, and low in the day). The diurnal change was abolished by adrenalectomy. Thyroparathyroidectomy alone did not prevent the diurnal change. It was abolished, however, when thyroparathyroidectomy was followed by a constant infusion of parathyroid hormone (0.8 U/h). These data indicate the presence of a diurnal rhythm of calcium and phosphate metabolism in rats and the involvement of parathyroid and adrenal hormones in the genesis of the rhythms.

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“…Conversely, the production of the active form of vitamin D 3 (lO:,25-dihydroxycholecalciferol) in the kidney is under the tight control of parathyroid hormone (Garabedian, Holick, DeLuca andBoyle 1972, Rasmussen, Wong, Bikle andGoodman 1972). Also in the target tissues, there is a mutual dependency between the actions of 1o:,25-dihydroxycholecalciferol and those of the parathyroid hormone (Rasmussen, DeLuca, Arnaud, Hawker andStedink 1963, Rasmussen, Bordier, Kurokawa, Nagata andOgata 1974).…”

mentioning

confidence: 99%

An Estimation of the Parathyroid Hormone Secretion Rate in Vitamin D Deficient Rats

Takahashi¹,

Shimazawa²,

Horiuchi³

et al. 1978

Horm Metab Res

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In an attempt to define the rate of endogenous secretion of parathyroid hormone in vitamin D deficiency, graded amounts of hormone were infused constantly into vitamin D deficient and vitamin D fed acutely thyroparathyroidectomized rats in a perfusion balance study. The dose of hormone needed to compensate for acute thyroparathyroidectomy was estimated. Serum levels of calcium and phosphorus, renal clearances of phosphorus and urinary excretion of cyclic AMP, each determined 16 hr after the surgery, were employed as parameters of the hormone effect. It was concluded that, in the condition of the perfusion balance study, the secretion rate of parathyroid hormone was 5.1-8.6 USP u/hr in the vitamin D deficient animals compared with 0.81-0.84 USP u/hr in the control.

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A transient increase in renal clearance of phosphate in response to continuous infusion of salmon calcitonin in rats.

Cited by 7 publications

References 10 publications

Salmon calcitonin-induced stimulation of 1α,25-dihydroxycholecalciferol synthesis in rats involving a mechanism independent of adenosine 3′:5′-cyclic monophosphate

Salmon calcitonin-induced stimulation of 1α,25-dihydroxycholecalciferol synthesis in rats involving a mechanism independent of adenosine 3′:5′-cyclic monophosphate

Diurnal Changes in Calcium and Phosphate Metabolism in Rats

An Estimation of the Parathyroid Hormone Secretion Rate in Vitamin D Deficient Rats

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