A Translational Approach to Hypertensive Heart Disease

Díez, Javier; Fröhlich, Edward D.

doi:10.1161/hypertensionaha.109.141887

Cited by 92 publications

(47 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…54 Fibrotic tissue accumulation with a change in spatial orientation of collagen fibres may progressively decrease diastolic filling and result in impaired LV contractility. 55 Despite normal EF in patients with HFPEF, it has been emphasised that contractile abnormalities and severe diastolic dysfunction are more common in HFPEF, unlike patients with hypertensive LVH. 56 LV volume studies have shown that the vast majority of HFPEF patients have normal endsystolic volume.…”

Section: Sympathetic Stimulation and Dynamics In Hypertension-mediatementioning

confidence: 99%

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

Yalçın

Küçukler

et al. 2010

J Hum Hypertens

View full text Add to dashboard Cite

Excessive sympathetic activity and stress-induced left ventricular (LV) hypercontractility have been described in hypertensive LV hypertrophy. Recent quantitative data have shown that hypertensive LV hypertrophy is associated with preserved global LV function. However, progression of uncontrolled hypertension have detrimental effects on both the ejection fraction (EF) and LV contractile response to stress. Hypertensive LV hypertrophy has some common characteristics, including preserved global LV systolic function and LV volume with heart failure with preserved EF (HFPEF), which makes it difficult to differentiate between the two conditions at rest. Studies suggest that adopting an efficient antihypertensive therapy regimen may positively effect on the LV contractile capability in patients with long-standing hypertension. Evaluation of quantitative LV contractility under stress may be beneficial to differentiate between the hypertensive LV hypertrophy and HFPEF. It may also assist in developing a more effective modality in medical management of patients with hypertensive heart disease.

show abstract

Section: Sympathetic Stimulation and Dynamics In Hypertension-mediatementioning

confidence: 99%

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

Yalçın

Küçukler

et al. 2010

J Hum Hypertens

View full text Add to dashboard Cite

show abstract

“…1 Although the mechanisms underlying this process remain incompletely understood, available evidence from the last two decades indicates that chronic haemodynamic overload has a driving role in activating LV myocardial growth; in turn, non-haemodynamic variables (that is, genetic, ethnic, environmental and hormonal factors) modulate the extent (and type) of the hypertrophic response. 2 --4 LVH in hypertensive patients may be regarded as a powerful, independent biomarker reflecting the impact of pressure overload as well as of several risk factors 5 on the heart.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of left-ventricular hypertrophy in hypertension: an updated review of echocardiographic studies

et al. 2011

View full text Add to dashboard Cite

on behalf of the Italian Society of Hypertension Left-ventricular hypertrophy (LVH) is a cardinal manifestation of hypertensive organ damage associated with an increased cardiovascular (CV) risk. We reviewed recent literature on the prevalence of LVH, as assessed by echocardiography, in order to offer an updated information on the magnitude of subclinical alterations in LV structure in contemporary human hypertension. A MEDLINE search using key words 'left ventricular hypertrophy', 'hypertension', 'echocardiography' and 'cardiac organ damage' was performed in order to identify relevant papers. Full articles published in English language in the last decade, (1 January 2000 --1 December 2010), reporting studies in adult or elderly individuals, were considered. A total of 30 studies, including 37 700 untreated and treated patients (80.3% Caucasian, 52.4% men, 9.6% diabetics, 2.6% with CV disease) were considered. LVH was defined by 23 criteria; its prevalence ranged from 36% (conservative criteria) to 41% (less conservative criteria) in the pooled population. LVH prevalence was not different between women and men (range 37.9 --46.2 versus 36.0 --43.5%, respectively). Eccentric LVH was more frequent than concentric hypertrophy (range 20.3 --23.0 versus 14.8 --15.8, respectively, Po0.05); concentric phenotype was found in a consistent fraction (20%) of both genders. Despite the improved management of hypertension in the last two decades, LVH remains a highly frequent biomarker of cardiac damage in the hypertensive population. Our analysis calls for a more aggressive treatment of hypertension and related CV risk factors leading to LVH. INTRODUCTIONLeft ventricular hypertrophy (LVH) secondary to arterial hypertension is a complex cardiac phenotype resulting from the response of myocyte and non-myocyte components to mechanical and neuro-humoral stimuli. 1 Although the mechanisms underlying this process remain incompletely understood, available evidence from the last two decades indicates that chronic haemodynamic overload has a driving role in activating LV myocardial growth; in turn, non-haemodynamic variables (that is, genetic, ethnic, environmental and hormonal factors) modulate the extent (and type) of the hypertrophic response. 2 --4 LVH in hypertensive patients may be regarded as a powerful, independent biomarker reflecting the impact of pressure overload as well as of several risk factors 5 on the heart.Routinely assessed LVH by electrocardiography or more accurately by echocardiography, is a strong determinant of cardiovascular (CV) prognosis over and beyond conventional risk factors in both population-based studies and in selected hypertensive cohorts. 6 --8 Initial levels of LV mass and mass reduction during antihypertensive treatment define CV risk related to subclinical cardiac damage 9 and influence therapeutic strategies. 10 In recent years, observational and interventional studies addressing hypertensive LVH performed worldwide 5 --9,11,12 offered us the opportunity to update available information o...

show abstract

“…In the year 2016, Hypertensive cardiopathy is the target organ damage with the highest morbidity and mortality. It is de ined as a group of complex and variable effects which cause chronic arterial pressure elevation in the heart and is characterized by the presence of anatomical and biochemical signs of left ventricular hypertrophy (LVH) or diastolic or systolic ventricular dysfunction, myocardial ischemia and cardiac rhythm alterations [4].…”

Section: Htn Affects a Quarter Of The Adult Population (78 Millions mentioning

confidence: 99%

Non-hemodynamic factors associated to the risk of developing hypertensive cardiopathy

Álvarez-Aliaga¹

2017

J Cardiol Cardiovasc Med

View full text Add to dashboard Cite

A Translational Approach to Hypertensive Heart Disease

Cited by 92 publications

References 60 publications

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

Prevalence of left-ventricular hypertrophy in hypertension: an updated review of echocardiographic studies

Non-hemodynamic factors associated to the risk of developing hypertensive cardiopathy

Contact Info

Product

Resources

About