A translational approach to the mind–brain–body connection.

Abstract

Mental and physical health are closely tied, and a deeper understanding of how the mind, brain, and body are connected has the potential to substantially improve health outcomes. In particular, a translational approach that integrates research on mind–brain–body connections at multiple levels of analysis (e.g., basic science, patient-oriented, and intervention science perspectives) can contribute toward the development, targeting, and implementation of mechanistically informed and effective interventions to improve mental and physical health. The three articles in this special issue elucidate a range of biological and behavioral mechanisms within the mind, brain, and body that contribute to health. The varying levels of analysis examined in each article complement each other to arrive at deeper insights than any one article would alone. Taken together, their research highlights the added value of moving from separate mental and physical health care models toward holistic care, and of considering how context may inform “for whom” a given intervention is most effective.

Can a translational science approach change the dementia narrative in medical education?

“…Increased awareness and education during the early stages of medical education may help to bridge this gap (Tullo and Gordon, 2013 ; Chan et al, 2022 ). Considering the complexity of dementia care (Dreier-Wolfgramm et al, 2017 ), addressing stigma via “a translational approach that integrates across multiple levels of analysis, from basic science to intervention research” (Querdasi and Callaghan, 2023 , p. 104) may facilitate a person-centered culture to reduce dementia-related stigma in medicine.…”