The relationships between the therapeutic alliance, within session processes, and psychotherapy outcome have been well-evidenced across models of psychotherapy. Despite a traditional focus on dyadic therapeutic relationships, emerging studies suggest that a systemic view of the alliance in individual therapy is related to client outcome. The current study evaluated therapist's alliance activity, quality of the systemic alliance, and therapist comfort as related to individual psychotherapy outcome. Results from multilevel modeling analyses of 247 individual therapy clients suggest client outcome improves when therapists overtly checked in about the therapeutic alliance, when therapists were rated as being more comfortable, and when clients' social networks were aligned with goals and tasks of treatment. Further, therapist alliance activity and client outcome was moderated by the systemic alliance, meaning clients whose therapist checked in more experienced better outcomes, especially for those whose social networks were not aligned with therapeutic goals and processes.