A Translational Randomized Trial of Perioperative Arginine Immunonutrition on Natural Killer Cell Function in Colorectal Cancer Surgery Patients

Angka, Leonard; Martel, Andre B.; Ng, Janet; Pecarskie, Amanda; Sadiq, Manahil; Jeong, Ahwon; Scaffidi, Marlena; Souza, Christiano Tanese de; Kennedy, Michael A.; Tadros, Shaheer; Auer, Rebecca C.

doi:10.1245/s10434-022-12202-y

Cited by 7 publications

(9 citation statements)

References 49 publications

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“…Although an emerging trend is to provide probiotic organisms to ‘repopulate’ the gut microbiome prior to surgery, such approaches are based on poorly designed observational studies that lack a compelling mechanistic basis to their function [36 ▪ ,37]. Other approaches suggest that ‘immunonutrition’ via a chemically defined, sterile, fiber-free liquid diet can ‘redirect’ the microbiome and immune system toward a recovery directed response to surgery [38,39]. Yet leveraging the power of one's own microbiome by providing it with its preferred substrate using a short-term plant based, high fiber low fat diet appears to be most supported by credible science.…”

Section: Rapid Modification Of the Gut Microbiome With Short-term Die...mentioning

confidence: 99%

“…These findings offer the opportunity to modulate the gut microbiome to facilitate rapid uneventful recovery in patients undergoing major anastomotic surgery. Although an emerging trend is to provide probiotic organisms to 'repopulate' the gut microbiome prior to surgery, such approaches are based on poorly designed observational studies that lack a compelling mechanistic basis to their function [36 can 'redirect' the microbiome and immune system toward a recovery directed response to surgery [38,39]. Yet leveraging the power of one's own microbiome by providing it with its preferred substrate using a short-term plant based, high fiber low fat diet appears to be most supported by credible science.…”

Section: Rapid Modification Of the Gut Microbiome With Short-term Die...mentioning

confidence: 99%

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The role of dietary prehabilitation on anastomotic healing

Alverdy

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review As the microbiome takes center stage in biomedical research and emerging medical treatments, here we review the scientific basis and role of dietary modulation to prevent anastomotic leakage. Recent Findings It is becoming increasingly clear that dietary habits have a profound influence on an individual's microbiome and that the microbiome plays a key and causative role in anastomotic leak etiology and pathogenesis. A review of recent studies indicates that the gut microbiome can become significantly shifted in composition, community structure and function within an extremely short time period of 2 or 3 days simply by changing one's diet. Summary From a practical standpoint to improve outcome from surgery, these observations, when paired with next generation technology, suggest that it is now possible to manipulate the microbiome of surgical patients to their advantage prior to surgery. This approach will allow surgeons to modulate the gut microbiome with the endpoint of improving the outcome from surgery. Thus a new emerging field termed ‘dietary prehabilitation’ is now gaining popularity and similar to smoking cessation, weight loss and exercise, may be a practical method to prevent postoperative complications including anastomotic leak.

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Section: Rapid Modification Of the Gut Microbiome With Short-term Die...mentioning

confidence: 99%

Section: Rapid Modification Of the Gut Microbiome With Short-term Die...mentioning

confidence: 99%

The role of dietary prehabilitation on anastomotic healing

Alverdy

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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“…[22] Finally, the role of arginine in enhancing natural killer cell function in colorectal surgery has been showcased in a single-center translational RCT study. [23] Table 1 summarizes the study designs in these articles. 2002 [17] Matsuda et al, 2006 [19] Finco et al, 2007 [20] Moya et al, 2016 [21] Moya et al, 2016 [22] Angka et al, 2022 [23] Study only enrolled January to September).…”

Section: Review Of High-quality Articlesmentioning

confidence: 99%

“…[23] Table 1 summarizes the study designs in these articles. 2002 [17] Matsuda et al, 2006 [19] Finco et al, 2007 [20] Moya et al, 2016 [21] Moya et al, 2016 [22] Angka et al, 2022 [23] Study only enrolled January to September). The search terms ("immunonutrition") AND ("preoperative" OR "perioperative" OR "postoperative") AND ("colorectal cancer" OR "colorectal carcinoma") AND ("immunonutrition") AND ("preoperative" OR "perioperative" OR "postoperative") were used, respectively.…”

Section: Review Of High-quality Articlesmentioning

confidence: 99%

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Immunonutrition of perioperative therapy for colorectal cancer

Chang

Hsu

2022

Formos J Surg

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Immunonutrition, a modified nutritional formula that involves the addition of glutamine, arginine, omega-3 fatty acids, nucleotides, and other potential compounds to the diet, has proven its potential for use in immunomodulation and protein metabolism improvement. Its clinical benefits include shortening hospital stays and lowering surgical infectious complications in upper gastrointestinal surgery. However, the use of perioperative immunonutrition is rare among colorectal cancer patients undergoing surgical intervention. Colorectal cancer is one of the most common cancers around the world, but its malnutrition rate is not high in comparison with other cancers (eg, gastric cancer or esophageal cancer). Furthermore, the surgical modality for the majority of colorectal cancer patients involves minimal invasive surgery (MIS), which enhances recovery speed. It is an interesting clinical question whether or not perioperative immunonutrition supplementation for colorectal cancer patients undergoing MIS causes extraclinical impacts. The immunomodulation effect of CD4+ T cells has been proven in colorectal patients undergoing elective surgery. In recent years, there have been several prospective randomized studies elucidating the clinical effects of immunonutrition on colorectal cancer patients undergoing surgery in Western countries. These studies have generally found that perioperative immunonutrition was associated with a lower rate of surgical infectious complications even in normo-nourished patients undergoing MIS. The use of perioperative immunonutrition provides clinical benefits according to high-quality studies. However, most results come from Western countries, and its effect needs to be validated in Asian countries.

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Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics

Li,

2024

Critical Reviews in Oncology/Hematology

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A Translational Randomized Trial of Perioperative Arginine Immunonutrition on Natural Killer Cell Function in Colorectal Cancer Surgery Patients

Cited by 7 publications

References 49 publications

The role of dietary prehabilitation on anastomotic healing

The role of dietary prehabilitation on anastomotic healing

Immunonutrition of perioperative therapy for colorectal cancer

Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics

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