A transmission electron microscopy study of mineralization in age-induced transparent dentin

Porter, Alexandra E.; Nalla, Ravi K.; Minor, Andrew M.; Jinschek, Joerg R.; Kisielowski, Christian; Radmilović, Velimir; Kinney, J.H.; Tomsia, Antoni P.; Ritchie, Robert O.

doi:10.1016/j.biomaterials.2005.05.059

Cited by 104 publications

(94 citation statements)

References 39 publications

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“…Orientation of dentin crystallites and collagen as determined by our SAXS measurements are in reasonable agreement with literature [7,10,11,31,32,39,47,63,64]. We additionally extracted the degree of orientation as a measure of local specimen anisotropy.…”

Section: Dentinsupporting

confidence: 82%

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Understanding Nano-Anatomy of Healthy and Carious Human Teeth: a Prerequisite for Nanodentistry

et al. 2012

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The anatomy of human teeth reflects its usage. Spatially resolved X-ray scattering permits quantitative studies of the characteristic arrangement of the anisotropic calcium phosphate crystallites and the collagen fibers within the hard tissues of the crown. The present study summarizes the distinctive nanometer-sized anatomical features of the tooth hard tissues including their interface taking advantage of spatially resolved synchrotron radiation-based small-angle X-ray scattering. The comparison of slices from eight teeth indicates a long-range organization of tooth nanostructures.

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Section: Dentinsupporting

confidence: 82%

“…Dentin abuts on dental enamel and acts as energy-absorbing, crackresistant structure [6]. Much effort has been devoted to understand the detailed composition and the microstructure of tubules [7][8][9][10][11][12], as well as their relationship to fracture toughness [6,13]. The interface between dentin and enamel, i.e.…”

Section: Introductionmentioning

confidence: 99%

Understanding Nano-Anatomy of Healthy and Carious Human Teeth: a Prerequisite for Nanodentistry

et al. 2012

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“…17,18 In contrast to bone, there is no remodeling after tooth growth is completed. During aging, human dentin sclerosis causes the tubules to become occluded through deposition of carbonated apatite 19,20 leading to transparency to visual light of the dentin (termed "transparent" dentin); this leads to changes in the mechanical properties, most notably a loss in ductility, toughness and cyclic fatigue resistance.…”

Section: Structurementioning

confidence: 99%

Aging and fracture of human cortical bone and tooth dentin

Koester

Ager

Ritchie

2008

JOM

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Mineralized tissues, such as bone and tooth dentin, serve as structural materials in the human body and, as such, have evolved to resist fracture. In assessing their quantitative fracture resistance or toughness, it is important to distinguish between intrinsic toughening mechanisms which function ahead of the crack tip, such as plasticity in metals, and extrinsic mechanisms which function primarily behind the tip, such as crack bridging in ceramics. Bone and dentin derive their resistance to fracture principally from extrinsic toughening mechanisms which have their origins in the hierarchical microstructure of these mineralized tissues. Experimentally, quantification of these toughening mechanisms requires a crack-growth resistance approach, which can be achieved by measuring the crack-driving force, e.g., the stress intensity, as a function of crack extension ("R-curve approach"). Here this methodology is used to study of the effect of aging on the fracture properties of human cortical bone and human dentin in order to discern the microstructural origins of toughness in these materials.

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“…In coronal dentine, there is a significant reduction in the strength, energy required to fracture and fracture toughness with increasing age. [13][14][15] However, little research has been undertaken on root dentine until now, except for Kinney et al, 12 and Porter et al, 16 who found that the mineral concentrations and crystallite size of root dentine changed with age. Whether there are changes in the mechanical properties of aged root dentine is unclear.…”

Section: Introductionmentioning

confidence: 99%

The effects of ageing on the biomechanical properties of root dentine and fracture

Zheng

Shao

et al. 2014

Journal of Dentistry

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j o u r n a l o f d e n t i s t r y 4 2 ( 2 0 1 4 ) 3 0 5 -3 1 1 a r t i c l e i n f o Objectives: Knowledge of the mechanical behaviour of root dentine can facilitate better understanding of spontaneous vertical root fracture (VRF), an age-related disease initiated mainly at the root apex. We tested the hypothesis that the biomechanical properties of root dentine change with ageing.Methods: Sixteen human premolars were divided into ''old'' (17-30 years) and ''young'' (50-80 years) groups. The elastic modulus, nano-hardness, micro-hardness, elemental contents, tubular density/area of root dentine in cervical, middle and apical root regions were evaluated using atomic force microscopy-based nano-indentation, Knoop indentation, scanning electron microscopy and energy dispersive X-ray spectroscopy, respectively. Results:The apical dentine showed a lower nano-hardness, a lower elastic modulus, a lower calcium content, a lower calcium-to-phosphorus ratio and a smaller tubular density/area than the cervical dentine in both age groups, whereas spatial differences in micro-hardness were observed only in old roots. Compared with young dentine, old dentine showed a greater hardness, a higher elastic modulus, a greater mineral content and a smaller tubular size in the cervical portion, whereas the age-induced changes in tubular density were insignificant. Finite element analysis revealed that due to its higher elastic modulus, old apical dentine has a higher stress level than young dentine. Conclusions:The intrinsic material properties of root dentine have spatial variations, and they are altered by ageing. The higher stress level in old apical dentine may be one reason, if not the most important one, why spontaneous VRFs are more likely to occur in the elderly population.

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A transmission electron microscopy study of mineralization in age-induced transparent dentin

Cited by 104 publications

References 39 publications

Understanding Nano-Anatomy of Healthy and Carious Human Teeth: a Prerequisite for Nanodentistry

Understanding Nano-Anatomy of Healthy and Carious Human Teeth: a Prerequisite for Nanodentistry

Aging and fracture of human cortical bone and tooth dentin

The effects of ageing on the biomechanical properties of root dentine and fracture

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