2009
DOI: 10.1016/j.ydbio.2009.05.009
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A travelling niche: Steel factor controls primordial germ cell survival and motility throughout their migration

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“…Our results are also remarkable in showing that the activity of a single receptor/ligand couple can result in the two opposite but temporally coexisting biological outcomes of MCC mutual repulsion and affinity for outer-layer junctions. Although these two phenomena might seem difficult to reconcile, the Scf/Kit signalling system has already been shown to promote apparently contrasting cell behaviours, such as migration and homing/adhesion, for example in melanoblasts (Jordan and Jackson, 2000;Wehrle-Haller and Weston, 1995), Hematopoietic Stem Cells (HSCs) (Heissig et al, 2002;Tajima et al, 1998) and Primordial Germ Cells (PGCs) (Gu et al, 2009;Gu et al, 2011;Runyan et al, 2006). Currently, the simplest and most widely accepted explanation, supported by in vivo, ex vivo and in vitro data, is that the membrane-bound and the soluble forms of the Scf (Ma et al, 2014).…”
Section: Implementation Of Xenopus MCC Patterning By the Scf/kit Pathwaymentioning
confidence: 99%
“…Our results are also remarkable in showing that the activity of a single receptor/ligand couple can result in the two opposite but temporally coexisting biological outcomes of MCC mutual repulsion and affinity for outer-layer junctions. Although these two phenomena might seem difficult to reconcile, the Scf/Kit signalling system has already been shown to promote apparently contrasting cell behaviours, such as migration and homing/adhesion, for example in melanoblasts (Jordan and Jackson, 2000;Wehrle-Haller and Weston, 1995), Hematopoietic Stem Cells (HSCs) (Heissig et al, 2002;Tajima et al, 1998) and Primordial Germ Cells (PGCs) (Gu et al, 2009;Gu et al, 2011;Runyan et al, 2006). Currently, the simplest and most widely accepted explanation, supported by in vivo, ex vivo and in vitro data, is that the membrane-bound and the soluble forms of the Scf (Ma et al, 2014).…”
Section: Implementation Of Xenopus MCC Patterning By the Scf/kit Pathwaymentioning
confidence: 99%