A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk

Berry, Sarah D.; Coppieters, Wouter; Davis, Stephen R.; Burrett, Alayna; Thomas, Natalie; Palmer, David J.; Kelly, Van; Obolonkin, Victor; Sanders, K.; Spelman, Richard; Georges, Michel; Lehnert, Klaus; Snell, Russell G.

doi:10.1371/journal.pone.0057219

Cited by 11 publications

(11 citation statements)

References 30 publications

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“…The cross-breed pedigree consisted of a subset of 864 F2 New Zealand Holstein-Friesian × Jersey (FJX) dairy cows representing the half-sib daughters of six F1 sires [29] . This pedigree was comprised of two cohorts bred over successive years and located on the same research farm, which is a resource that has been used previously for the discovery of QTL and causative genes and variations [30] – [32] . The mixed ancestry (MA) population consisted of 32,530 female dairy cows located on commercial dairy farms throughout New Zealand, forming part of a large phenotypic and genotypic database of animals used for evaluation of sire performance.…”

Section: Methodsmentioning

confidence: 99%

Expression Variants of the Lipogenic AGPAT6 Gene Affect Diverse Milk Composition Phenotypes in Bos taurus

et al. 2014

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Milk is composed of a complex mixture of lipids, proteins, carbohydrates and various vitamins and minerals as a source of nutrition for young mammals. The composition of milk varies between individuals, with lipid composition in particular being highly heritable. Recent reports have highlighted a region of bovine chromosome 27 harbouring variants affecting milk fat percentage and fatty acid content. We aimed to further investigate this locus in two independent cattle populations, consisting of a Holstein-Friesian x Jersey crossbreed pedigree of 711 F2 cows, and a collection of 32,530 mixed ancestry Bos taurus cows. Bayesian genome-wide association mapping using markers imputed from the Illumina BovineHD chip revealed a large quantitative trait locus (QTL) for milk fat percentage on chromosome 27, present in both populations. We also investigated a range of other milk composition phenotypes, and report additional associations at this locus for fat yield, protein percentage and yield, lactose percentage and yield, milk volume, and the proportions of numerous milk fatty acids. We then used mammary RNA sequence data from 212 lactating cows to assess the transcript abundance of genes located in the milk fat percentage QTL interval. This analysis revealed a strong eQTL for AGPAT6, demonstrating that high milk fat percentage genotype is also additively associated with increased expression of the AGPAT6 gene. Finally, we used whole genome sequence data from six F1 sires to target a panel of novel AGPAT6 locus variants for genotyping in the F2 crossbreed population. Association analysis of 58 of these variants revealed highly significant association for polymorphisms mapping to the 5′UTR exons and intron 1 of AGPAT6. Taken together, these data suggest that variants affecting the expression of AGPAT6 are causally involved in differential milk fat synthesis, with pleiotropic consequences for a diverse range of other milk components.

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Section: Methodsmentioning

confidence: 99%

Expression Variants of the Lipogenic AGPAT6 Gene Affect Diverse Milk Composition Phenotypes in Bos taurus

et al. 2014

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“…as a result, the genomes of the majority of domestic livestock species probably have a mosaic structure that is at least as pronounced as that of the laboratory mouse 192 or human 193 . some haplotypes segregating within pig and cattle breeds have been shown to differ approximately every 100 bp, which is a similar sequence identity to humans and chimpanzees; thus, they possibly coalesced ~5 million years ago, which is before the creation of the studied species 118,194,195 .…”

Section: Box 1 | Genetic Variation Provides Insight Into the Domesticmentioning

confidence: 99%

Harnessing genomic information for livestock improvement

2018

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The world demand for animal-based food products is anticipated to increase by 70% by 2050. Meeting this demand in a way that has a minimal impact on the environment will require the implementation of advanced technologies, and methods to improve the genetic quality of livestock are expected to play a large part. Over the past 10 years, genomic selection has been introduced in several major livestock species and has more than doubled genetic progress in some. However, additional improvements are required. Genomic information of increasing complexity (including genomic, epigenomic, transcriptomic and microbiome data), combined with technological advances for its cost-effective collection and use, will make a major contribution.

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“…Gene polymorphisms and haplotypes of receptor genes are the crucial factor to the antibody production and livability of the neonates ( 41 , 46 – 48 ). In order to harvest antibody-enriched colostrum or milks, Ig bioreactors could be bred by genetic engineering with respect to FcRn and pIgR on the basis of their polymorphisms and haplotype research.…”

Section: Current Understanding About the Regulations Of Fcrn And Pigrmentioning

confidence: 99%

“…One of the haplotypes (the β 2 M 2, 2) showed an increased risk of failure for Igs transfer ( 47 ). Researchers have also identified three divergent haplotypes of pIgR and explained the variation in the concentration of SIgA and the pIgR level ( 46 ). Genome-wide analysis identified a significant association between SIgA and six SNPs located in the PIGR, PIGR-2, PIGR-5, PIGR-9, PIGR-13, PIGR-17, and PIGR-19.…”

Section: Current Understanding About the Regulations Of Fcrn And Pigrmentioning

confidence: 99%

Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor

Jiang

Diraviyam

et al. 2016

Front. Immunol.

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The functions of immunoglobulin transporting receptors (Ig transporting receptors) in immune system encompass from passive immunity to adaptive immunity by transporting immunoglobulins (Igs) and prolonging their half-life as well as enhancing immunosurveillance. Prior to the weaning, Ig transportations from mother to offspring confer the immediate passive immunity for neonates. After the weaning, FcRn and polymeric immunoglobulin receptor on infant intestinal epithelial cells retrieve Ig in intestinal lamina propria into the gut lumen for preventing pathogen invasion. This is not only improving the pathological consequences of infection but also helping the neonates for developing their own immune response; besides it would be the guidance for designing novel vaccines. Moreover, the investigations on Ig transporting receptors over-expressed transgenic animals have been carried out to improve Ig concentrations in serum and milk; thus, it would be a sustainable method to produce antibody-enriched milk-derived colostrum replacer for neonates. In order to generate mammary gland bioreactor, a series of methods have been developed for enhanced regulation of Ig transporting receptors expression and Ig transportation.

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A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk

Cited by 11 publications

References 30 publications

Expression Variants of the Lipogenic AGPAT6 Gene Affect Diverse Milk Composition Phenotypes in Bos taurus

Expression Variants of the Lipogenic AGPAT6 Gene Affect Diverse Milk Composition Phenotypes in Bos taurus

Harnessing genomic information for livestock improvement

Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor

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