A trial of preoperative radiotherapy in the management of operable rectal cancer

Duncan, W.; Smith, A. N.; Freedman, Laurence S.; Alderson, M R; Arnott, S.J.; Bleehen, N. M.; Bond, W. H.; Crowther, Derek; Deeley, T. J.; Duthie, H. L.; Dykes, P. W.; Fielding, L P; Flatman, G. E.; Goligher, J. C.; Hawley, P. R.; Hughes, L E; Joslin, C. A.; Koriech, Osama M.; Morson, B. C.; Oates, G. D.; Peckham, M. J.; Sandland, M R; Schofield, Philip F.; Slack, W.W.; Slaney, G; Smith, Jessica A.; Scott, John; Whitehouse, J. M. A.; Wrigley, P. F. M.; York-Mason, A

doi:10.1002/bjs.1800690906

Journal of British Surgery

1982

DOI: 10.1002/bjs.1800690906

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A trial of preoperative radiotherapy in the management of operable rectal cancer

W. Duncan¹,

A. N. Smith²,

Laurence S. Freedman³

et al.

Abstract: A trial of preoperative radiotherapy in the management of operable rectal cancerIn a multicentre study, 824 patients with operable rectal cancer were randomized to receive surgery alone, surgery plus a single fraction of 500 rad ( 5 Gy) and surgery plus 2000 rad (20 Gy) in 10 equal daily, i.e. multiple, fractions. The ratio of abdominoperineal excision to anterior restorative operations was 3 : 1. There was no evidence of an increased morbidity or mortality following irradiation. The multiple fraction 2000 rad… Show more

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Cited by 70 publications

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Interim analysis of a phase III study on preoperative radiation therapy in resectable rectal carcinoma. Trial of the gastrointestinal tract cancer cooperative group of the European organization for research on treatment of cancer (EORTC)

Gérard

Berrod

Pene

et al. 1985

Cancer

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To improve surgical results of potentially operable rectal cancer (T2, T3, T4, Mo), the European Organization for Research on Treatment of Cancer (EORTC) conducted a two‐arm randomized clinical trial to evaluate the effect of administering radiotherapy before radical surgery. Four hundred ten patients were allocated to be treated either by surgery alone or by 34.5 Gy of radiotherapy (in 19 days overall) followed by surgery. The tolerance of the adjuvant radiation therapy was fairly good. The 5‐year survival rate was 65% overall and showed no difference between both therapeutic regimens. Similarly, the metastases‐free rate was the same in both groups. In contrast, the preoperative radiation therapy showed a marked effect on local control of the disease, the comparison of the time to local recurrence being highly significant between the two treatment groups (P = 0.001). The proportion of patients free of local recurrence at 5 years was 85% in the combined treatment versus 65% in the group of patients treated by surgery alone.

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Interim analysis of a phase III study on preoperative radiation therapy in resectable rectal carcinoma. Trial of the gastrointestinal tract cancer cooperative group of the European organization for research on treatment of cancer (EORTC)

Gérard

Berrod

Pene

et al. 1985

Cancer

View full text Add to dashboard Cite

show abstract

Low-dose preoperative radiation postpones recurrences in operable rectal cancer: Results of a randomized multicenter trial in western norway

Dahl

Horn

Morild

et al. 1990

Cancer

177

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A randomized, multicenter clinical trial was conducted in Western Norway to study the effectiveness of preoperative radiation therapy in operable rectal cancer, given at a dosage of 3150 cGy in 18 fractions, 2 to 3 weeks before radical surgery. Three hundred nine patients were entered into the trial between May 1976 and December 1985. After radiation no tumor was seen in 4.5% of the patients. There was no increased morbidity or mortality at surgery. The 5-year survival for evaluable patients was 57.5% in the control group and 56.7% in the radiotherapy group. For patients operated on for cure the 5-year survival was 60.9% and 64.2% in the control group and radiotherapy group, respectively. Radiation significantly delayed both local and distant recurrences in patients in the radiation group who had curative resection from 13.3 months in controls to 27.1 months. The local recurrence rate in the corresponding groups was 21.1% and 13.7%, respectively. We conclude that higher preoperative radiation doses should be used in new trials as a higher dosage may transform the observed positive effects into a survival benefit.

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Pre-operative radiotherapy and curative surgery for the management of localized rectal carcinoma

Wong

Tandan

Silva

et al. 2007

Cochrane Database of Systematic Reviews

167

123

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A trial of preoperative radiotherapy in the management of operable rectal cancer

Cited by 70 publications

References 1 publication

Interim analysis of a phase III study on preoperative radiation therapy in resectable rectal carcinoma. Trial of the gastrointestinal tract cancer cooperative group of the European organization for research on treatment of cancer (EORTC)

Interim analysis of a phase III study on preoperative radiation therapy in resectable rectal carcinoma. Trial of the gastrointestinal tract cancer cooperative group of the European organization for research on treatment of cancer (EORTC)

Low-dose preoperative radiation postpones recurrences in operable rectal cancer: Results of a randomized multicenter trial in western norway

Pre-operative radiotherapy and curative surgery for the management of localized rectal carcinoma

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