A Trial of Pulsed Xenon Ultraviolet Disinfection to Reduce C. Difficile Infection

Sampathkumar, Priya; Nation, Larry; Folkert, Carla; Wentink, Jean E.; Zavaleta, Kathryn W.

doi:10.1016/j.ajic.2016.04.022

Cited by 5 publications

(25 citation statements)

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“…42 Of the 20 studies, 13 (65%) used a UVL disinfection system, 24,26,28,31,32,[34][35][36][37][38][39]41,42 and 7 studies (35%) used an HPV disinfection system. 23,25,27,29,30,33,40 Of the UVL disinfection system studies, 24,26,28,31,32,[34][35][36][37][38][39]41,42 8 studies used pulsed Xenon UVL (PX-UV), 24,26,28,32,35,36,38,42 4 studies used UV-C radiation (UV-C), 34,37,39,41 and 1 study did not specify the type of UVL. 31 Most of the studies included in our review were conducted in the United States (17 studies) 23,24,…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…23,25,27,29,30,33,40 Of the UVL disinfection system studies, 24,26,28,31,32,[34][35][36][37][38][39]41,42 8 studies used pulsed Xenon UVL (PX-UV), 24,26,28,32,35,36,38,42 4 studies used UV-C radiation (UV-C), 34,37,39,41 and 1 study did not specify the type of UVL. 31 Most of the studies included in our review were conducted in the United States (17 studies) 23,24,26,[28][29][30][31][32][34][35][36][37][38][39][40][41][42] ; 2 studies were performed in the United Kingdom…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…24,26,28,31,32,[34][35][36][37][38][39]41,42 Studies varied on the type of rooms that used the no-touch technology. The majority of the studies used no-touch technology after terminal cleaning of rooms of patients on contact precautions (11 studies), 23,25,27,29,30,33,34,36,[38][39][40][41][42] but other studies evaluated the no-touch technology after terminal cleaning of all patient rooms hospital-wide (4 studies), 28,31,32,37 after terminal cleaning in oncology units (2 studies), 34,42 and ICU patient rooms 26,35 (2 studies, 1 of which also used no-touch technology after terminal cleaning in the operating room of a burn unit). 26 Another study investigated no-touch technology after terminal cleaning in all operating rooms hospital-wide.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…24,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] The longest study time was 6 years (an HPV system study) 33 and the shortest study duration <1 year (a UVL system study). 42 Many of the UVL and HPV studies included in our review were conducted at community medical centers (12 studies) 24,[27][28][29][30][31][32][33]35,[37][38][39] ; 6 studies were performed at academic medical centers 23,25,34,36,40,42 ; and 1 study was performed at a military medical center. 26 One study 41 was conducted in 9 hospitals: 6 community medical centers, 2 academic medical centers, and 1 Veterans Affairs medical center.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…For HPV systems, 4 studies were performed at community medical centers 27,29,30,33 and 3 studies were performed at academic medical centers. 23,25,40 The outcome for the majority of the studies (17 studies) was CDI rates 23,25,[27][28][29][30][31][32][34][35][36][37][38][39][40][41][42] ; among these, 11 were studies of UVL disinfection systems 28,31,32,[34][35][36][37][38][39]41,42 and 6 were studies of HPV disinfection systems. 23,25,27,29,30,40 For the UVL disinfection system baseline CDI rates, 6 studies were considered to have a high baseline rate (≥1.5 per 1,000 patient days) 28,31,32,34,41,42 and 5 studies had a low baseline CDI rate (<1.5 per 1,000 patient days).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

See 4 more Smart Citations

No-Touch Disinfection Methods to Decrease Multidrug-Resistant Organism Infections: A Systematic Review and Meta-analysis

Marra

Schweizer

Edmond

2017

Infect. Control Hosp. Epidemiol.

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BACKGROUND Recent studies have shown that using no-touch disinfection technologies (ie, ultraviolet light [UVL] or hydrogen peroxide vapor [HPV] systems) can limit the transmission of nosocomial pathogens and prevent healthcare-associated infections (HAIs). To investigate these findings further, we performed a systematic literature review and meta-analysis on the impact of no-touch disinfection methods to decrease HAIs. METHODS We searched PubMed, CINAHL, CDSR, DARE and EMBASE through April 2017 for studies evaluating no-touch disinfection technology and the nosocomial infection rates for Clostridium difficile, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and other multidrug-resistant organisms (MDROs). We employed random-effect models to obtain pooled risk ratio (pRR) estimates. Heterogeneity was evaluated with I2 estimation and the Cochran Q statistic. Pooled risk ratios for C. difficile, MRSA, VRE, and MDRO were assessed separately. RESULTS In total, 20 studies were included in the final review: 13 studies using UVL systems and 7 studies using HPV systems. When the results of the UVL studies were pooled, statistically significant reduction ins C. difficile infection (CDI) (pRR, 0.64; 95% confidence interval [CI], 0.49-0.84) and VRE infection rates (pRR, 0.42; 95% CI, 0.28-0.65) were observed. No differences were found in rates of MRSA or gram-negative multidrug-resistant pathogens. CONCLUSIONS Ultraviolet light no-touch disinfection technology may be effective in preventing CDI and VRE infection. Infect Control Hosp Epidemiol 2018;39:20-31.

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Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

See 3 more Smart Citations

No-Touch Disinfection Methods to Decrease Multidrug-Resistant Organism Infections: A Systematic Review and Meta-analysis

Marra

Schweizer

Edmond

2017

Infect. Control Hosp. Epidemiol.

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Effectiveness of ultraviolet disinfection in reducing hospital-acquired Clostridium difficile and vancomycin-resistant Enterococcus on a bone marrow transplant unit

Brite

McMillen

Robilotti

et al. 2018

Infect. Control Hosp. Epidemiol.

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Hospital surface disinfection using ultraviolet germicidal irradiation technology: A review

Scott

Joshi

McGinn

2022

Healthcare Tech Letters

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Ultraviolet germicidal irradiation (UVGI) technologies have emerged as a promising alternative to biocides as a means of surface disinfection in hospitals and other healthcare settings. This paper reviews the methods used by researchers and clinicians in deploying and evaluating the efficacy of UVGI technology. The type of UVGI technology used, the clinical setting where the device was deployed, and the methods of environmental testing that the researchers followed are investigated. The findings suggest that clinical UVGI deployments have been growing steadily since 2010 and have increased dramatically since the start of the COVID‐19 pandemic. Hardware platforms and operating procedures vary considerably between studies. Most studies measure efficacy of the technology based on the objective measurement of bacterial bioburden reduction; however, studies conducted over longer durations have examined the impact of UVGI on the reduction of healthcare associated infections (HCAIs). Future trends include increased automation and the use of UVGI technologies that are safer for use around people. Although existing evidence seems to support the efficacy of UVGI as a tool capable of reducing HCAIs, more research is needed to measure the magnitude of these effects and to establish recommended best practices.

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A Trial of Pulsed Xenon Ultraviolet Disinfection to Reduce C. Difficile Infection

Cited by 5 publications

References 0 publications

No-Touch Disinfection Methods to Decrease Multidrug-Resistant Organism Infections: A Systematic Review and Meta-analysis

No-Touch Disinfection Methods to Decrease Multidrug-Resistant Organism Infections: A Systematic Review and Meta-analysis

Effectiveness of ultraviolet disinfection in reducing hospital-acquired Clostridium difficile and vancomycin-resistant Enterococcus on a bone marrow transplant unit

Hospital surface disinfection using ultraviolet germicidal irradiation technology: A review

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