A trial of verapamil in the treatment of stuttering in adults

Treatment with medications affecting dopaminergic and serotonergic mechanisms: Effects on fluency and anxiety in persons who stutter

“…This is supported by reports from previous studies using anxiolytic medications that have not always demonstrated improvement in fluency either (e.g. Brady, Price, McAllister, & Dietrich, 1989;Brumfitt & Peake, 1988;DiCarlo, Katz, & Batkin, 1959;Fish & Bowling, 1965;Holliday, 1959;Kent, 1963;Kent & Williams, 1959;Kymissis & Martin, 1990;Maxwell & Paterson, 1958;Rustin, Kuhr, Cook, & James, 1981;Zachariah, 1980). However, improvements in percent fluent speaking time were associated, again non-significantly, with decreased speech-related anxiety (as measured by the VAS).…”

Improvement of stuttering with use of methylphenidate in a child who was diagnosed with concomitant stuttering and ADHD

“…10 SSRIs such as citalopram, escitalopram, tricyclic antidepressants such as clomipramine and benzodiazepines such as alprazolam were in-_____________________________________________________________________________________________________ vestigated in the treatment of stuttering and beneficial effects were reported. 11,12 In our literature research, we considered that the agents that were investigated in the treatment of stuttering are limited to studies which were not confirmed or case reports. Regarding the amelioration of stuttering with methylphenidate in our case, it is emphasized that further studies are needed to clarify the place of methylphenidate extended release in the treatment of stuttering.…”

Propriospinal myoclonus in ischemic myelopathy secondary to a spinal dural arteriovenous fistula

“…3 Pharmacologic data led to postulate a dopaminergic mechanism underlying stuttering. 25 Finally, developmental stuttering is commonly associated with secondary behaviors, such as head turning, blinking, or upper lip raising. [21][22][23] Verapamil, a calcium channel blocker known to induce or aggravate parkinsonism and other extrapyramidal symptoms, 24 has also been tried for stuttering.…”

“…25 (39) On/off rating (one score for "on" and one score for "off") 23 (37) Best/worst rating (one score for "at best" and one score for "at worst") 5 (8) Combination 10 (16) With a variety of scoring methods used for the Schwab & England scale, it is important to determine if one method depicts patients more accurately than another. With several people participating in this fundamental assessment, there is danger of lack of consistency, which may be a problem for research reliability.…”