A tribute: Abel Ayerza and pulmonary hypertension: Figure 1.

Mazzei, Juan Antonio; Mazzei, Mariano E.

doi:10.1183/09059180.00006811

Cited by 14 publications

(17 citation statements)

References 2 publications

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“…He described dilated and thickened wall bronchi full of secretions. The pulmonary arteries showed thrombus obstructing the lumen and hyperplasia of both middle and intima layers, with new glomerular-like “formed channels” blocking the pulmonary vessels 31 . Dr Ayerza called it “ cardíaco negro ” (black heart), due to the extreme cyanosis observed in this patient.…”

Section: Increasing Interest In Pulmonary Hypertension 27mentioning

confidence: 99%

Pulmonary hypertension: From an orphan disease to a global epidemic

Butrous

2020

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[No abstract. Showing first paragraph of article]Pulmonary hypertension is a progressive disease characterized by an elevation of pulmonary artery pressure and pulmonary vascular resistance, leading to right ventricular failure and death. It remains a challenging chronic progressive disease, but the current interest and advent of medical therapy in the last 20 years has significantly changed the perception of medical community in this disease. Pulmonary hypertension is not a specific disease; the majority of cases present with other diseases and various pathological processes that affect the pulmonary vasculature, and consequently increase pulmonary pressure and vascular resistance.

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Section: Increasing Interest In Pulmonary Hypertension 27mentioning

confidence: 99%

Pulmonary hypertension: From an orphan disease to a global epidemic

Butrous

2020

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“…Pathological changes in the pulmonary arteries co-existing with right ventricular hypertrophy (RVH) were first observed by the German physician Ernst von Romberg toward the end of the nineteenth century, which he coined “pulmonary vascular sclerosis” (11). However, the etiology of PH remained elusive at this time and was wrongly attributed to syphilis for many years (12, 13). Whilst the British cardiologist Oscar Brenner eventually disproved this link in 1935, he could not provide an explanation for pulmonary vascular changes coinciding with RVH (14).…”

Section: Pulmonary Hypertension: a Historymentioning

confidence: 99%

Thin Air, Thick Vessels: Historical and Current Perspectives on Hypoxic Pulmonary Hypertension

2019

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The association between pulmonary hypertension (PH) and hypoxia is well-established, with two key mechanistic processes, hypoxic pulmonary vasoconstriction and hypoxia-induced vascular remodeling, driving changes in pulmonary arterial pressure. In contrast to other forms of pulmonary hypertension, the vascular changes induced by hypoxia are reversible, both in humans returning to sea-level from high altitude and in animal models. This raises the intriguing possibility that the molecular drivers of these hypoxic processes could be targeted to modify pulmonary vascular remodeling in other contexts. In this review, we outline the history of research into PH and hypoxia, before discussing recent advances in our understanding of this relationship at the molecular level, focussing on the role of the oxygen-sensing transcription factors, hypoxia inducible factors (HIFs). Emerging links between HIF and vascular remodeling highlight the potential utility in inhibiting this pathway in pulmonary hypertension and raise possible risks of activating this pathway using HIF-stabilizing medications.

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“…The first clinical case series of pulmonary hypertension came from Argentina. Ayerza had described a patient with a chronic productive cough, dyspnoea, severe cyanosis and right heart failure in 1901 which he termed ‘cardíaco negro’ (black heart) due to the significant cyanosis 15 . His student Arrillaga published a series of 11 cases in 1913 as his doctoral thesis and the disease became known as Ayerza's disease 16 .…”

Section: The First Age: Pathologymentioning

confidence: 99%