A Trifunctional Dextran-Based Nanovaccine Targets and Activates Murine Dendritic Cells, and Induces Potent Cellular and Humoral Immune Responses In Vivo

Shen, Limei; Higuchi, Tetsuya; Tubbe, Ingrid; Voltz, Nicole; Krummen, Mathias; Pektor, Stefanie; Montermann, Evelyn; Rausch, Kristin; Schmidt, Manfred; Schild, Hansjörg; Grabbe, Stephan; Bros, Matthias

doi:10.1371/journal.pone.0080904

Cited by 25 publications

(16 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dextran is water soluble and is easy to modify with other functional groups to achieve environment responsive properties. Though crystalized dextran particles can serve as vaccine delivery vehicle as reported (Schröder and Ståhl, 1984;Shen et al, 2013), most studies have focused on modified dextran as a candidate for vaccine design. In this section, we discuss only modified dextran.…”

Section: Modified Dextranmentioning

confidence: 99%

Carbohydrate Conjugates in Vaccine Developments

Lang

Huang

2020

Front. Chem.

View full text Add to dashboard Cite

Vaccines are powerful tools that can activate the immune system for protection against various diseases. As carbohydrates can play important roles in immune recognition, they have been widely applied in vaccine development. Carbohydrate antigens have been investigated in vaccines against various pathogenic microbes and cancer. Polysaccharides such as dextran and β-glucan can serve as smart vaccine carriers for efficient antigen delivery to immune cells. Some glycolipids, such as galactosylceramide and monophosphoryl lipid A, are strong immune stimulators, which have been studied as vaccine adjuvants. In this review, we focus on the current advances in applying carbohydrates as vaccine delivery carriers and adjuvants. We will discuss the examples that involve chemical modifications of the carbohydrates for effective antigen delivery, as well as covalent antigen-carbohydrate conjugates for enhanced immune responses.

show abstract

Section: Modified Dextranmentioning

confidence: 99%

Carbohydrate Conjugates in Vaccine Developments

Lang

Huang

2020

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…Incorporation of OVA and lipopolysaccharide in dextran NPs stimulated APCs in a mannose receptor-dependent manner as well as strong cellular (OVA peptide-specific CD4+ and CD8+ T cell) and humoral immune responses in mice [127]. Incorporation of OVA and lipopolysaccharide in dextran NPs stimulated APCs in a mannose receptor-dependent manner as well as strong cellular (OVA peptide-specific CD4+ and CD8+ T cell) and humoral immune responses in mice [127].…”

Section: Dextran and Biopolymer Combinationsmentioning

confidence: 99%

Biodegradable polymers for modern vaccine development

Bose

Kim

Chang

et al. 2019

Journal of Industrial and Engineering Chemistry

View full text Add to dashboard Cite

A B S T R A C TMost traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy. This review summarizes the potential of biodegradable materials, including synthetic and natural polymers, for vaccine delivery. These materials are highly biocompatible and have minimal toxicity, and most biomaterial-based vaccines delivering antigens or adjuvants have been shown to improve immune response, compared to formulations consisting of the antigen alone. Therefore, these materials can be applied in modern vaccine development.

show abstract

“…Non‐AcDEX did not show any immunostimulatory property per se and was used to co‐encapsulate OVA and lipopolysaccharide into a nanovaccine formulation. It allowed, however, an enhanced uptake by APC in a mannose receptor‐dependent manner, leading to an enhanced immunostimulation in vitro and in vivo …”

Section: Plga Particlesmentioning

confidence: 99%

Delivery of therapeutics with nanoparticles: what's new in cancer immunotherapy?

Fontana

Liu

Hirvonen

et al. 2016

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

The application of nanotechnology to the treatment of cancer or other diseases has been boosted during the last decades due to the possibility to precise deliver drugs where needed, enabling a decrease in the drug's side effects. Nanocarriers are particularly valuable for potentiating the simultaneous co-delivery of multiple drugs in the same particle for the treatment of heavily burdening diseases like cancer. Immunotherapy represents a new concept in the treatment of cancer and has shown outstanding results in patients treated with check-point inhibitors. Thereby, researchers are applying nanotechnology to cancer immunotherapy toward the development of nanocarriers for delivery of cancer vaccines and chemo-immunotherapies. Cancer nanovaccines can be envisioned as nanocarriers co-delivering antigens and adjuvants, molecules often presenting different physicochemical properties, in cancer therapy. A wide range of nanocarriers (e.g., polymeric, lipid-based and inorganic) allow the co-formulation of these molecules, or the delivery of chemo- and immune-therapeutics in the same system. Finally, there is a trend toward the use of biologically inspired and derived nanocarriers. In this review, we present the recent developments in the field of immunotherapy, describing the different systems proposed by categories: polymeric nanoparticles, lipid-based nanosystems, metallic and inorganic nanosystems and, finally, biologically inspired and derived nanovaccines. WIREs Nanomed Nanobiotechnol 2017, 9:e1421. doi: 10.1002/wnan.1421 For further resources related to this article, please visit the WIREs website.

show abstract

A Trifunctional Dextran-Based Nanovaccine Targets and Activates Murine Dendritic Cells, and Induces Potent Cellular and Humoral Immune Responses In Vivo

Cited by 25 publications

References 35 publications

Carbohydrate Conjugates in Vaccine Developments

Carbohydrate Conjugates in Vaccine Developments

Biodegradable polymers for modern vaccine development

Delivery of therapeutics with nanoparticles: what's new in cancer immunotherapy?

Contact Info

Product

Resources

About