A Trimodality Comparison of Volumetric Bone Imaging Technologies. Part III: SD, SEE, LSC Association With Fragility Fractures

Wong, Andy Kin On; Beattie, Karen A.; Min, Kevin K.H.; Merali, Zamir; Webber, Colin E.; Gordon, Christopher L.; Παπαϊωάννου, Αλεξάνδρα; Cheung, Angela M.; Adachi, Jonathan D.

doi:10.1016/j.jocd.2014.07.003

Cited by 4 publications

(9 citation statements)

References 32 publications

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“…Nevertheless, these apparent micro-architecture traits differ substantially from traits obtained via high-resolution pQCT (117) , and at this time there seems to be no additional diagnostic value, or clinical utility over standard pQCT-measured vBMD (121) .…”

Section: Voxel Size Selectionmentioning

confidence: 77%

Peripheral Quantitative Computed Tomography: Review of Evidence and Recommendations for Image Acquisition, Analysis, and Reporting, Among Individuals With Neurological Impairment

Cervinka

Giangregorio

Sievänen

et al. 2018

Journal of Clinical Densitometry

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In 2015, the International Society for Clinical Densitometry (ISCD) position statement regarding peripheral quantitative computed tomography (pQCT) did not recommend routine use of pQCT, in clinical settings until consistency in image acquisition and analysis protocols are reached, normative studies conducted, and treatment thresholds identified. To date, the lack of consensus-derived recommendations regarding pQCT implementation remains a barrier to implementation of pQCT technology. Thus, based on description of available evidence and literature synthesis, this review recommends the most appropriate pQCT acquisition and analysis protocols for clinical care and research purposes, and recommends specific measures for diagnosis of osteoporosis, assigning fracture risk, and monitoring osteoporosis treatment effectiveness, among patients with neurological impairment. A systematic literature search of MEDLINE, EMBASE, CINAHL, and PubMed for available pQCT studies assessing bone health was carried out from inception to August 8th, 2017. The search was limited to individuals with neurological impairment (spinal cord injury, stroke, and multiple sclerosis) as these groups have rapid and severe regional declines in bone mass. Of 923 references, we identified 69 that met review inclusion criteria. The majority of studies (n = 60) used the Stratec XCT 2000/3000 pQCT scanners as reflected in our evaluation of acquisition and analysis protocols. Overall congruence with the ISCD Official Positions was poor. Only 11% (n = 6) studies met quality reporting criteria for image acquisition and 32% (n = 19) reported their data analysis in a format suitable for reproduction. Therefore, based on current literature synthesis, ISCD position statement standards and the authors' expertise, we propose acquisition and analysis protocols at the radius, tibia, and femur sites using Stratec XCT 2000/3000 pQCT scanners among patients with neurological impairment for clinical and research purposes in order to drive practice change, develop normative datasets and complete future meta-analysis to inform fracture risk and treatment efficacy evaluation.

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Section: Voxel Size Selectionmentioning

confidence: 77%

Peripheral Quantitative Computed Tomography: Review of Evidence and Recommendations for Image Acquisition, Analysis, and Reporting, Among Individuals With Neurological Impairment

Cervinka

Giangregorio

Sievänen

et al. 2018

Journal of Clinical Densitometry

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“…Sixteen of 25 studies included women only, ( 10,11,18‐21,23,26‐31,34‐36 ) six studies men only, ( 12,13,22,24,32,37 ) and three studies both genders. ( 14,25,33 ) For ethnicity, the 25 studies included participants as follows: seven French, ( 10,13,18‐20,22,35 ) five American, ( 12,21,28,29,32 ) four Swedish, ( 24,27,31,37 ) two Canadian, ( 11,23 ) two British, ( 25,34 ) two multiple, ( 14,30 ) one Swiss, ( 36 ) one Asian, ( 26 ) and one Brazilian. ( 33 ) In summary, seven were from North America, one from South America, 14 from Europe, one from Asia, and two from multiple countries (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The full texts of 151 papers were retrieved for further assessment of eligibility; 126 papers were further excluded, because these studies did not involve fracture discrimination or prediction. Hence, 25 papers were finally included in this systematic review including 18 case–control studies ( 10 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ) and seven cohort studies. ( 11 , 12 , 13 , 14 , 35 , 36 , 37 ) Out of 25 papers, only 16 papers were included for meta‐analysis, in which there were 11 case–control studies ( 10 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ) and five cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…Hence, 25 papers were finally included in this systematic review including 18 case–control studies ( 10 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ) and seven cohort studies. ( 11 , 12 , 13 , 14 , 35 , 36 , 37 ) Out of 25 papers, only 16 papers were included for meta‐analysis, in which there were 11 case–control studies ( 10 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ) and five cohort studies. ( 11 , 12 , 13 , 35 , 36 ) Figure 1 summarizes the selection process of the included papers.…”

Section: Resultsmentioning

confidence: 99%

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Best Performance Parameters of HR-pQCT to Predict Fragility Fracture: Systematic Review and Meta-Analysis

Cheung

Hung

Cheuk

et al. 2020

Journal of Bone and Mineral Research

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Osteoporosis is a systemic skeletal disease characterized by low bone mass and bone structural deterioration that may result in fragility fractures. Use of bone imaging modalities to accurately predict fragility fractures is always an important issue, yet the current gold standard of dual‐energy X‐ray absorptiometry (DXA) for diagnosis of osteoporosis cannot fully satisfy this purpose. The latest high‐resolution peripheral quantitative computed tomography (HR‐pQCT) is a three‐dimensional (3D) imaging device to measure not only volumetric bone density, but also the bone microarchitecture in a noninvasive manner that may provide a better fracture prediction power. This systematic review and meta‐analysis was designed to investigate which HR‐pQCT parameters at the distal radius and/or distal tibia could best predict fragility fractures. A systematic literature search was conducted in Embase, PubMed, and Web of Science with relevant keywords by two independent reviewers. Original clinical studies using HR‐pQCT to predict fragility fractures with available full text in English were included. Information was extracted from the included studies for further review. In total, 25 articles were included for the systematic review, and 16 articles for meta‐analysis. HR‐pQCT was shown to significantly predict incident fractures and/or major osteoporotic fractures (MOFs). Of all the HR‐pQCT parameters, our meta‐analysis revealed that cortical volumetric bone mineral density (Ct.vBMD), trabecular thickness (Tb.Th), and stiffness were better predictors. Meanwhile, HR‐pQCT parameters indicated better performance in predicting MOFs than incident fractures. Between the two standard measurement sites of HR‐pQCT, the non‐weight‐bearing distal radius was a more preferable site than distal tibia for fracture prediction. Furthermore, most of the included studies were white‐based, whereas very few studies were from Asia or South America. These regions should build up their densitometric databases and conduct related prediction studies. It is expected that HR‐pQCT can be used widely for the diagnosis of osteoporosis and prediction of future fragility fractures. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

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“…For bone outcomes, we used analysis modes based on the study by Ashe, et al (26). We considered cortical thickness as the primary cortical structure outcome of interest since the study by Ashe et al demonstrated that cortical thickness was the cortical geometry measure with the greatest correlation with fracture load (R 2 =0.81, p<0.001) and previous studies identified associations with risk of fracture (27). Trabecular vBMD also correlates highly with fracture load (R 2 =0.72 P<0.001) (28, 29).…”

Section: Methodsmentioning

confidence: 99%

Muscle Deficits in Rheumatoid Arthritis Contribute to Inferior Cortical Bone Structure and Trabecular Bone Mineral Density

et al. 2017

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Objective Rheumatoid arthritis (RA) is associated with muscle loss, osteoporosis, and fracture. We examined associations between skeletal muscle mass, strength, and quality and trabecular and cortical bone deficits in patients with RA and healthy controls. Methods Participants, ages 18–75 years, completed whole-body DXA and peripheral quantitative CT of the tibia to quantify appendicular lean mass and fat mass indices (ALMI, FMI),, muscle density at the lower leg, trabecular bone density, and cortical bone thickness. Age-, sex-, and race-specific Z-Scores were calculated based on distributions in controls. Associations between body composition and pQCT bone outcomes were assessed in RA and controls. Linear regression analyses assessed differences in bone outcomes after considering differences in body mass index (BMI) and body composition. Results The sample consisted of 112 RA patients (55 men) and 412 controls (194 men). Compared to controls, RA patients had greater BMI (p=0.004), lower ALMI after adjustment for FMI (p=0.02), lower muscle strength (p=0.006), and lower muscle density (p<0.0001). Among RA, ALMI Z-Scores were positively associated with trabecular density [β: 0.29 (0.062,0.52) p=0.01] and cortical thickness [β: 0.32 (0.13,0.53) p=0.002]. Associations were similar in controls. Bone outcomes were inferior in RA patients after adjusting for BMI but similar to controls when adjusting for body composition. Radiographic damage and higher adiponectin levels were independently associated with inferior bone outcomes. Conclusions Patients with RA exhibit deficits in cortical bone structure and trabecular density at the tibia and a preserved functional muscle-bone unit. A loss of mechanical loading may contribute to bone deficits.

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A Trimodality Comparison of Volumetric Bone Imaging Technologies. Part III: SD, SEE, LSC Association With Fragility Fractures

Cited by 4 publications

References 32 publications

Peripheral Quantitative Computed Tomography: Review of Evidence and Recommendations for Image Acquisition, Analysis, and Reporting, Among Individuals With Neurological Impairment

Peripheral Quantitative Computed Tomography: Review of Evidence and Recommendations for Image Acquisition, Analysis, and Reporting, Among Individuals With Neurological Impairment

Best Performance Parameters of HR-pQCT to Predict Fragility Fracture: Systematic Review and Meta-Analysis

Muscle Deficits in Rheumatoid Arthritis Contribute to Inferior Cortical Bone Structure and Trabecular Bone Mineral Density

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