A Triode-like Enzyme-free Catalytic Circuit with Junction Fuel

Principles of nucleic acid toehold mediated strand displacement (TMSD) reaction model and its applications in cell environment

“…Nucleic acid TMSD reaction generally contains three reaction processes, including toehold association, branch migration, and strand dissociation. 57,58 Firstly, the invader strand binds with the gate strand through the toehold domain. Then, the invader strand starts the branch migration process, owing to thermal perturbation.…”

Information processing based on DNA toehold-mediated strand displacement (TMSD) reaction

“…24 Then, several complex reaction networks or patterns were devised to perform more sophisticated functions ranging from structure manipulation, [25][26][27][28] algorithm investigation such as half/full adder, 29 square-rooting function, [30][31][32] network communication, [33][34][35][36][37] DNA algorithm logic unit, 38 and oscillator, 39,40 to diagnostic therapy including drug delivery systems [41][42][43][44][45] and sensing. 20,25,[46][47][48][49][50][51][52][53][54][55]…”