A triterpenoid saponin from Cyclamen coum

Yaylı, Nurettin; Baltacı, Cemalettin; Zengin, Ali; Küçükislamoğlu, Mustafa; Genç, Hasan

doi:10.1016/s0031-9422(97)00978-3

Cited by 21 publications

(18 citation statements)

References 9 publications

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“…Compounds (1)- (6) were identified on the basis of HR-MS spectroscopy, accurate 1D and 2D NMR experiments (DQF-COSY, TOCSY, HMQC and HMBC) and by comparison of their spectral data with those reported in the literature as deglucocyclamin (1) (Calis et al, 1997b), lysikokianoside (2) (Kohda et al, 1989), anagalloside B (3) (Shoji et al, 1994), deglucoanagalloside B (4) (Shoji et al, 1994), coumoside A (5) (Yayli et al, 1998a) and coumoside B (6) (Yayli et al, 1998b). The purities of the isolated compounds were tested by HPLC and found to be 97% for integration by software.…”

Section: Plantmentioning

confidence: 99%

“…tubers exhibited in vitro cytotoxic (Kupchan et al, 1967), spermicidal (Primorac et al, 1985) and antimicrobial activities (Mahasneh and El-Oqlah, 1999). Early investigations on the different Cyclamen species resulted in the isolation of triterpenoid saponins (Calis et al, 1997a;1997b;Yayli et al, 1998a;1998b). To our knowledge no phytochemical and biological data are available on C. repandum.…”

Section: Introductionmentioning

confidence: 99%

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Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.

Speroni

Cervellati

Costa

et al. 2007

Phytotherapy Research

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According to folk medicine some species belonging to the genus Cyclamen were used for their biological activities. Early investigation of the different species of the genus resulted in the isolation of triterpenic saponins. No phytochemical and biological data are available on C. repandum. As part of a series of phytochemical investigations for bioactive compounds from medicinal plants, Cyclamen repandum S. et S. was investigated. The present study sought to find the antiinflammatory and antinociceptive activities of C. repandum tubers in rats and mice. A preliminary screening was conducted with three different extracts in the tests used, particularly the paw edema and the writhing tests. Subsequently some saponins isolated from the ME extract, the more effective one, have been identified. This paper also describes the results of fractionation and bioassay guided chemical studies. Chemical investigation of the active extract afforded the isolation and characterization of six triterpenic saponins. The possible antiinflammatory and analgesic properties were investigated as the saponin content of the fractions allows to speculate on such aspect.

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Section: Plantmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.

Speroni

Cervellati

Costa

et al. 2007

Phytotherapy Research

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“…6,7 The whole C. coum plant contains sterols, 8 piperidine alkaloid 2-β-D-glycopyranosyl-2-undecil-3,5-dihydroxy-6-carboxypiperidine, 9 and saponins as cyclaminorin, coumoside A, coumoside B, cyclacoumin, isocyclamin, deglucocyclamin and mirabilin lactone. [10][11][12][13] In folk medicine, the C. coum has been used for treatment of hemorrhages, ecchymosis, inflammations, hemorrhoids and cancer. 14,15 An evidence-based study conducted by Yildiz et al proved that C. coum crude extract induced moderate cytotoxicity and apoptosis in NSCLC H1299 and HeLa cancer cell lines and the degree of apoptosis and cytotoxicity on cervical cancer cell line HeLa is stronger than on NSCLC H1299 cell line.…”

Section: Introductionmentioning

confidence: 99%

“…26,27 Quercetin (10 mg) was dissolved in 10 mL of distilled water and was diluted to 100 mL. Subsequently, the stock solution was diluted to provide a series of concentrations (10,30,40,50,70, 100 μg/mL); from each solution, (1 mL) was mixed with 0.3 mL of 10% AlCl3, 0.3 mL of sodium nitrite, 1 mL of 2M NaOH and 1 mL of distilled water. The samples were incubated at room temperature for 30 minutes.…”

mentioning

confidence: 99%

Preliminary Phytochemical and Biological Screening of Cyclamen coum a Member of Palestinian Flora

Jaradat¹,

Al-Masri²,

Hussen³

et al. 2017

Pharm Sci

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“…The two main approaches adopted for the examination of analytes do not seem to satisfy the normal criteria of volatility for GC-MS. Either they are degraded under controlled conditions by pyrolysis to give characteristic volatile fragments, or they are derived from related compounds that are suitable for gas chromatography [10]. Low-molecular-weight hydrocarbons can be analyzed directly by GC-MS without volatile fragmentation.…”

mentioning

confidence: 99%

Identification of hydrocarbons from Abies pindrow leaves

et al. 2010

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The genus Abies family Pinaceae consists of 51 species ranged mainly in temperate and boreal regions of the northern hemisphere, chiefly in mountainous regions [1]. The literature data on phytochemical and biological investigations of the genus of Abies revealed that up to now, 277 compounds were isolated from 19 plants of Abies species. The chemical constituents are mostly terpenoids, flavonoids, and lignans, together with minor constituents of phenols, steroids, and others. The crude extracts and metabolites have been found to possess various bioactivities, including insect juvenile hormone, antitumor, antimicrobial, antiulcerogenic, antiinflammatory, antihypertensive, antitussive, and CNS (central nervous system) activities [2].Abies pindrow Royle, commonly known as west Himalayan fir, is a large evergreen tree growing up to 40-60 m tall with a trunk diameter of up to 2-2.5 m. It has a conical crown with level branches. In Pakistan, Abies pindrow Royle, known as partal or palundar, is widely distributed at elevations between 2000 and 3000 m throughout the western Himalayas from Afghanistan to Nepal [3]. Pindrow species of Abies is regarded as carminative, stomachic, astringent, expectorant, tonic, antispasmodic, and antiperiodic [4].Phytochemical studies of the species resulted in the isolation of glucopyranoside, hydroxyflavanone, chalcone glycoside, bioflavonoids, flavonoids and pindrolactone [5], and pentacyclic triterpenoids [6]. Different extracts from the leaves of Abies pindrow Royle exhibited anti-inflammatory, analgesic, and hypnotic activities in rats, attenuated swim stress in mice, and produced hypotension in dogs. Abies pindrow Royle leaves also have an antiulcerogenic effect on the cold-restrained gastric ulcer model in rats [5]. A review of the literature revealed that no hydrocarbons have yet been reported from Abies pindrow Royle.We have previously reported the fatty acid composition of the ethanol extract of the leaves of Abies pindrow Royle. A total of 11 fatty acids, including eight saturated and three unsaturated, was characterized [4].The present investigation of aerial part (leaves) of Abies pindrow Royle describes the occurrence of long chain hydrocarbons. The presence of these hydrocarbons is detected by GC-MS and supported by FTIR. A careful look at the fragmentation pattern in the mass spectral data reveals the presence of saturated and unsaturated hydrocarbons. These hydrocarbons have been reported for the first time from Abies pindrow Royle.The GC-MS of the hexane fraction revealed the presence of tricosane, eicosane, heneicosane, docosane, tetracosane, nonadecane, octadecane, 1-docosene, 1-octadecene, heptadecane, and 2,6,10,14-tetramethylhexadecane. The identity of these common hydrocarbons was made by comparison of these peaks with the standards by gas chromatography and confirmed by comparison of the fragmentation pattern with those of standard mass spectrum. FTIR analysis supported the structures of these hydrocarbons. The FTIR spectrum exhibits the diagnostic peaks relating t...

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A triterpenoid saponin from Cyclamen coum

Cited by 21 publications

References 9 publications

Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.

Analgesic and antiinflammatory activity of Cyclamen repandum S. et S.

Preliminary Phytochemical and Biological Screening of Cyclamen coum a Member of Palestinian Flora

Identification of hydrocarbons from Abies pindrow leaves

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