A trust approach for sharing research reagents

Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases.

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“…The comprehensive KCGS will be made available to all scientists that agree to be trustees of the set. [ 48 ]…”

Section: Kinases: Important Targets Untapped Opportunitiesmentioning

confidence: 99%

Progress towards a public chemogenomic set for protein kinases and a call for contributions

et al. 2017

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“…Principles described herein "The core feature of trusts-holding property for the benefit of others is well suited to constructing a research community that treats reagents as public goods." Edwards et al (2017). E.g.…”

Section: Democratizationmentioning

confidence: 98%

Foundations for Open Scholarship Strategy Development

Beamer¹,

Bosman²,

Brembs³

et al. 2019

Preprint

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This document aims to agree on a broad, international strategy for the implementation of open scholarship that meets the needs of different national and regional communities but works globally.Scholarly research can be idealised as an inspirational process for advancing our collective knowledge to the benefit of all humankind. However, current research practices often struggle with a range of tensions, in part due to the fact that this collective (or “commons”) ideal conflicts with the competitive system in which most scholars work, and in part because much of the infrastructure of the scholarly world is becoming largely digital. What is broadly termed as Open Scholarship is an attempt to realign modern research practices with this ideal. We do not propose a definition of Open Scholarship, but recognise that it is a holistic term that encompasses many disciplines, practices, and principles, sometimes also referred to as Open Science or Open Research. We choose the term Open Scholarship to be more inclusive of these other terms. When we refer to science in this document, we do so historically and use it as shorthand for more general scholarship.The purpose of this document is to provide a concise analysis of where the global Open Scholarship movement currently stands: what the common threads and strengths are, where the greatest opportunities and challenges lie, and how we can more effectively work together as a global community to recognise and address the top strategic priorities. This document was inspired by the Foundations for OER Strategy Development and work in the FORCE11 Scholarly Commons Working Group, and developed by an open contribution working group.Our hope is that this document will serve as a foundational resource for continuing discussions and initiatives about implementing effective strategies to help streamline the integration of Open Scholarship practices into a modern, digital research culture. Through this, we hope to extend the reach and impact of Open Scholarship into a global context, making sure that it is truly open for all. We also hope that this document will evolve as the conversations around Open Scholarship progress, and help to provide useful insight for both global co-ordination and local action. We believe this is a step forward in making Open Scholarship the norm.Ultimately, we expect the impact of widespread adoption of Open Scholarship to be diverse. We expect novel research practices to accelerate the pace of innovation, and therefore stimulate critical industries around the world. We could also expect to see an increase in public trust of science and scholarship, as transparency becomes more normative. As such, we expect interest in Open Scholarship to increase at multiple levels, due to its inherent influence on society and global economics.

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“…This gap also emphasizes the lack of a reliable and independent source of validated standard target proteins (Gilda et al, 2015;Quarmby et al, 1998). Given that there is a market for nearly 4×10 6 cr-Abs, it cannot be beyond human ingenuity to set up an international Public Interest Entity, which, on a not-for-profit basis, produces precisely defined proteomic targets, for example the principal components of the human and mouse proteomes, and verifies antibodies that recognize them in 'pillar' validation technologies (Colwill et al, 2011;Edwards et al, 2017;Zhong et al, 2015;Weller, 2016). These antibodies and target standards could then be certified and maintained as standard open-source reference pairs, routinely available under commercial terms, to help validate and align the specificity of other cr-Abs.…”

Section: R Is For Recombinantmentioning

confidence: 99%

The path to VICTORy – a beginner's guide to success using commercial research antibodies

S¹

2018

Journal of Cell Science

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Commercial research antibodies are crucial tools in modern cell biology and biochemistry. In the USA some $2 billion a year are spent on them, but many are apparently not fit-for-purpose, and this may contribute to the 'reproducibility crisis' in biological sciences. Inadequate antibody validation and characterization, lack of user awareness, and occasional incompetence amongst suppliers have had immense scientific and personal costs. In this Opinion, I suggest some paths to make the use of these vital tools more successful. I have attempted to summarize and extend expert views from the literature to suggest that sustained routine efforts should made in: (1) the validation of antibodies, (2) their identification, (3) communication and controls, (4) the training of potential users, (5) the transparency of original equipment manufacturer (OEM) marketing agreements, and (5) in a more widespread use of recombinant antibodies (together denoted the 'VICTOR' approach).

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A trust approach for sharing research reagents

Abstract: The core feature of trusts—holding property for the benefit of others—is well suited to constructing a research community that treats reagents as public goods.

Cited by 13 publications

References 6 publications

Progress towards a public chemogenomic set for protein kinases and a call for contributions

Progress towards a public chemogenomic set for protein kinases and a call for contributions

Foundations for Open Scholarship Strategy Development

The path to VICTORy – a beginner's guide to success using commercial research antibodies

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