A tutorial on generalized eigendecomposition for denoising, contrast enhancement, and dimension reduction in multichannel electrophysiology

Cohen, Michael X

doi:10.48550/arxiv.2104.12356

Cited by 1 publication

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“…One major advantage of this method is the ability to decompose multiple partially spatially overlapping networks. Indeed, it is possible that traditional electrode-based synchronization methods mix neurally and cognitively distinct interactions because a single electrode measures activity from multiple networks (Cunningham and Yu, 2014;Cohen, 2021).…”

Section: Lfp Microstates Reflect Mesoscale Rhythmic Coordination Acro...mentioning

confidence: 99%

Dynamics of Neural Microstates in the VTA–Striatal–Prefrontal Loop during Novelty Exploration in the Rat

et al. 2021

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Neural activity at the large-scale population level has been suggested to be consistent with a sequence of brief, quasistable spatial patterns. These "microstates" and their temporal dynamics have been linked to myriad cognitive functions and brain diseases. Most of this research has been performed using EEG, leaving many questions, such as the existence, dynamics, and behavioral relevance of microstates at the level of local field potentials (LFPs), unaddressed. Here, we adapted the standard EEG microstate analysis to triple-area LFP recordings from 192 electrodes in rats to investigate the mesoscopic dynamics of neural microstates within and across brain regions during novelty exploration. We performed simultaneous recordings from the prefrontal cortex, striatum, and ventral tegmental area in male rats during awake behavior (object novelty and exploration). We found that the LFP data can be accounted for by multiple, recurring microstates that were stable for ;60-100 ms. The simultaneous microstate activity across brain regions revealed rhythmic patterns of coactivations, which we interpret as a novel indicator of inter-regional, mesoscale synchronization. Furthermore, these rhythmic coactivation patterns across microstates were modulated by behavioral states such as movement and exploration of a novel object. These results support the existence of a functional mesoscopic organization across multiple brain areas and present a possible link of the origin of macroscopic EEG microstates to zero-lag neuronal synchronization within and between brain areas, which is of particular interest to the human research community.

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Section: Lfp Microstates Reflect Mesoscale Rhythmic Coordination Acro...mentioning

confidence: 99%

Dynamics of Neural Microstates in the VTA–Striatal–Prefrontal Loop during Novelty Exploration in the Rat

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

A tutorial on generalized eigendecomposition for denoising, contrast enhancement, and dimension reduction in multichannel electrophysiology

Cited by 1 publication

References 37 publications

Dynamics of Neural Microstates in the VTA–Striatal–Prefrontal Loop during Novelty Exploration in the Rat

Dynamics of Neural Microstates in the VTA–Striatal–Prefrontal Loop during Novelty Exploration in the Rat

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