1985
DOI: 10.1007/bf01065891
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A twin study of ethanol metabolism

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1986
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Cited by 127 publications
(71 citation statements)
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“…18 -24 Most high-risk studies of alcohol challenge performance have assumed, at least implicitly, a strong genetic determination of differences in postalcohol performance. Results from an alcohol challenge study conducted on a sample of Australian twins 25 ,26 confirm that a substantial portion of the postalcohol variation in body swar and self-report of intoxication 27 can be attributed to genetic effects. A metaanalysis of self-rated measures of intoxication 28 supports the premise that sons of alcoholics experience less intense intoxication in response to an acute dose of alcohol, and this is consistent with data from a lO-year follow-up of challenge study participants 29 ,30 that suggest that decreased ratings of self-intoxication measured in young men may predict alcohol dependence in later adulthood.…”
Section: Genetics and Alcohol Sensitivitymentioning
confidence: 85%
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“…18 -24 Most high-risk studies of alcohol challenge performance have assumed, at least implicitly, a strong genetic determination of differences in postalcohol performance. Results from an alcohol challenge study conducted on a sample of Australian twins 25 ,26 confirm that a substantial portion of the postalcohol variation in body swar and self-report of intoxication 27 can be attributed to genetic effects. A metaanalysis of self-rated measures of intoxication 28 supports the premise that sons of alcoholics experience less intense intoxication in response to an acute dose of alcohol, and this is consistent with data from a lO-year follow-up of challenge study participants 29 ,30 that suggest that decreased ratings of self-intoxication measured in young men may predict alcohol dependence in later adulthood.…”
Section: Genetics and Alcohol Sensitivitymentioning
confidence: 85%
“…Measures were taken more than once and averaged to compute a score that was then adjusted for height (further details in ref. 25). More negative scores indicated increased body sway.…”
Section: Methodsmentioning
confidence: 99%
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“…Independent linkage studies on several populations have indicated strong evidence for linkage between a locus on chromosome 4q containing ADH gene cluster and AD (Martin et al, 1985;Reich et al, 1998;Reich, 1996;Williams et al, 1999;Long et al, 1998). By comprehensive analysis testing the association between AD and 110 SNPs throughout the seven ADH genes, the most consistent evidence for an association has been observed for 12 SNPs in and around the ADH4 gene, while associations with SNPs in ADH1A and ADH1B were weaker, and there was no significant association with variations in ADH1C (Edenberg et al, 2006).…”
Section: Introductionmentioning
confidence: 84%