2016
DOI: 10.1063/1.4954812
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A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

Abstract: This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces… Show more

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Cited by 53 publications
(38 citation statements)
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“…In practice, the actual constant value of I * does not necessarily equal 0.5, depending instead on the measured pixel intensity of a premixed solution. To incorporate this into the calculation of mixing index, the following equation has been proposed for HSI images: italicMixing index=11Ni=1N()Ifalse¯italicHSI,iIfalse¯italicHSI,italicmixtrueI¯HSI,unmixtrueI¯HSI,mix2, where trueI¯ HSI ,mix is the normalized premixed pixel intensity, trueI¯ HSI ,unmix is the normalized pixel intensity prior to mixing, and trueI¯ HSI ,i is Ifalse¯italicHSI,normali=()IitalicHSI,iIitalicHSI,italicmin()IitalicHSI,italicmaxIitalicHSI,italicmin0.25em, where trueI¯ HSI ,i is the normalized pixel intensity inside the image, whereas I HSI, min and I gray, max are the minimum and maximum local pixel intensity, respectively, and I HSI, i is IHSI,normali=()normalR+normalG+normalB/3. …”
Section: Introductionmentioning
confidence: 99%
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“…In practice, the actual constant value of I * does not necessarily equal 0.5, depending instead on the measured pixel intensity of a premixed solution. To incorporate this into the calculation of mixing index, the following equation has been proposed for HSI images: italicMixing index=11Ni=1N()Ifalse¯italicHSI,iIfalse¯italicHSI,italicmixtrueI¯HSI,unmixtrueI¯HSI,mix2, where trueI¯ HSI ,mix is the normalized premixed pixel intensity, trueI¯ HSI ,unmix is the normalized pixel intensity prior to mixing, and trueI¯ HSI ,i is Ifalse¯italicHSI,normali=()IitalicHSI,iIitalicHSI,italicmin()IitalicHSI,italicmaxIitalicHSI,italicmin0.25em, where trueI¯ HSI ,i is the normalized pixel intensity inside the image, whereas I HSI, min and I gray, max are the minimum and maximum local pixel intensity, respectively, and I HSI, i is IHSI,normali=()normalR+normalG+normalB/3. …”
Section: Introductionmentioning
confidence: 99%
“…4 The mixing performance of these micromixers is generally characterized as a function of mixing index. On the basis of color changes, the mixing index has been employed to characterize mixing between dye colored liquids [5][6][7] , reaction between chemical that produces different colored species 8 , reaction between pH indicators [9][10][11] , and dilution of fluorescent liquids. 12,13 Several quantitative mixing indices have been defined based on intensity images recorded using typical digital video microscopes.…”
Section: Introductionmentioning
confidence: 99%
“…Such vortex shedding, whose frequency f —as characterized by a Strouhal number SrfL/U, in which L is the characteristic length scale of the posts and U the mean velocity of the flow between them—increases with a decrease in the feature aspect ratio and increasing longitudinal confinement of the flow between the posts, i.e., smaller pitch‐to‐post diameter ratios, and was shown to be effective not only to sufficiently permeabilize cell membranes in order to deliver an exogenous payload comprising various therapeutic molecules into the cell to aid transfection, but to also lyse the cells . Additionally, topology has also been combined with geometrical features to enhance vorticity generation in microchannels …”
Section: Passive Actuationmentioning
confidence: 99%
“…• Wall protrusions [49] • Grooves [160,161] • Posts -Flow deformation [50] -Vortex shedding [51,52] Combined with geometrical features [53][54][55] Simple, effective, and potentially low-cost Considerable pressure drop necessitates large benchtop pumps to drive the flow Not possible to tune centrifugation intensity independent of flow for a given device Dead volumes around corners in cavities, chambers, and sharp bends/turns can lead to particle deposition and fouling…”
Section: Geometrymentioning
confidence: 99%
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