A two-chip acoustofluidic particle manipulation platform with a detachable and reusable surface acoustic wave device

Qian, Jingui; Ren, Jifeng; Liu, Yi; Lam, Raymond H. W.; Lee, Joshua

doi:10.1039/d0an01469a

Cited by 15 publications

(10 citation statements)

References 24 publications

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“…This requires the transmission of SAW energy from the IDT substrate to the microchannel superstrate. Different coupling agents and strategies have been explored 65 – 67 . Ma et al designed a disposable TSAW-based separation device and successfully separated PS particles with sizes of 10 and 15 μm 68 .…”

Section: Mechanisms Of Acoustofluidic Separationmentioning

confidence: 99%

Recent advances in acoustofluidic separation technology in biology

et al. 2022

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Acoustofluidic separation of cells and particles is an emerging technology that integrates acoustics and microfluidics. In the last decade, this technology has attracted significant attention due to its biocompatible, contactless, and label-free nature. It has been widely validated in the separation of cells and submicron bioparticles and shows great potential in different biological and biomedical applications. This review first introduces the theories and mechanisms of acoustofluidic separation. Then, various applications of this technology in the separation of biological particles such as cells, viruses, biomolecules, and exosomes are summarized. Finally, we discuss the challenges and future prospects of this field.

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Section: Mechanisms Of Acoustofluidic Separationmentioning

confidence: 99%

Recent advances in acoustofluidic separation technology in biology

et al. 2022

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“…Using light and acoustic waves [1] is the most practical way to reach this aim. Surface acoustic waves (SAWs) have been receiving extensive attention on various research and application areas related to delay lines [2], filters [3,4], microfluidics [5][6][7], gas-detection [8,9], mass detection [10] and biodetection applications [11,12]. Due to these wide ranges of research and application areas, SAW devices have drawn significant interest in recent decades.…”

Section: Introductionmentioning

confidence: 99%

Influence of the Core Pillar Height on the Bandgap Characteristics of Piezoelectric Phononic Crystals with Ring-Shaped Grooves

Kuruoğlu

2022

Cumhuriyet Science Journal

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Dispersion profiles and surface acoustic wave attenuation characteristics of ring-shaped phononic crystals are investigated as a function of the core pillar height. Finite element method simulations are carried out for both band analyses and transmission spectra calculations. The results reveal that increasing core pillar height results in a decrement in the local resonance band frequency and the corresponding transmission peaks. The obtained dispersion profiles show that the phononic crystal bandgap also expands from 6 MHz to 11 MHz while the pillar height increases from 5 um to 7 um. Similar characteristics are also seen in the transmission spectra for the varying core pillar heights of the ring-shaped periodic grooves. In addition, surface acoustic wave attenuation competency depends on the core pillar height. The frequencies where the investigated phononic crystals are functional can be tuned by adjusting the core pillar height.

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“…The bottom of the microchannel coupled in this way may be uneven, and there may be leakage, deformation, and other problems. In their works [ 19 , 27 ], the microchannel had to be replaced with a new one after several uses due to the reduced adhesion of the underside seal. Jingui Qian et al [ 27 ] added a hard substrate (silicon) on previous basis to improve coupling efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…In their works [ 19 , 27 ], the microchannel had to be replaced with a new one after several uses due to the reduced adhesion of the underside seal. Jingui Qian et al [ 27 ] added a hard substrate (silicon) on previous basis to improve coupling efficiency. Polymer films were added between the SAW device and the silicon layer to achieve reliable fixation of the detachable acoustic flow device, and the stability was improved.…”

Section: Introductionmentioning

confidence: 99%

A Novel Detachable, Reusable, and Versatile Acoustic Tweezer Manipulation Platform for Biochemical Analysis and Detection Systems

Liu

Zhang

et al. 2022

Biosensors

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Multifunctional, integrated, and reusable operating platforms are highly sought after in biochemical analysis and detection systems. In this study, we demonstrated a novel detachable, reusable acoustic tweezer manipulation platform that is flexible and versatile. The free interchangeability of different detachable microchannel devices on the acoustic tweezer platform was achieved by adding a waveguide layer (glass) and a coupling layer (polydimethylsiloxane (PDMS) polymer film). We designed and demonstrated the detachable multifunctional acoustic tweezer platform with three cell manipulation capabilities. In Demo I, the detachable acoustic tweezer platform is demonstrated to have the capability for parallel processing and enrichment of the sample. In Demo II, the detachable acoustic tweezer platform with capability for precise cell alignment is demonstrated. In Demo III, it was demonstrated that the detachable acoustic tweezer platform has the capability for the separation and purification of cells. Through experiments, our acoustic tweezer platform has good acoustic retention ability, reusability, and stability. More capabilities can be expanded in the future. It provides a simple, economical, and multifunctional reusable operating platform solution for biochemical analysis and detection systems.

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A two-chip acoustofluidic particle manipulation platform with a detachable and reusable surface acoustic wave device

Abstract: This work describes a two-chip acoustofluidic platform for two-dimensional (2D) manipulation of microparticles in a closed microchamber on a reusable surface acoustic wave (SAW) device. This platform comprises two microfabricated...

Cited by 15 publications

References 24 publications

Recent advances in acoustofluidic separation technology in biology

Recent advances in acoustofluidic separation technology in biology

Influence of the Core Pillar Height on the Bandgap Characteristics of Piezoelectric Phononic Crystals with Ring-Shaped Grooves

A Novel Detachable, Reusable, and Versatile Acoustic Tweezer Manipulation Platform for Biochemical Analysis and Detection Systems

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