2020
DOI: 10.1136/bmjopen-2018-028575
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A two-part model to estimate inpatient, outpatient, prescribing and care home costs associated with atrial fibrillation in Scotland

Abstract: ObjectiveThis study aimed to estimate global inpatient, outpatient, prescribing and care home costs for patients with atrial fibrillation using population-based, individual-level linked data.DesignA two-part model was employed to estimate the probability of resource utilisation and costs conditional on positive utilisation using individual-level linked data.SettingsScotland, 5 years following first hospitalisation for AF between 1997 and 2015.ParticipantsPatients hospitalised with a known diagnosis of AF or at… Show more

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Cited by 18 publications
(17 citation statements)
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“…Healthcare expenditure data have mixed distributions, characterized by a disproportionate proportion of zero‐cost observations (nonusers) and a right‐skewed distribution 10 . Therefore, we introduced a two‐part model to identify what factors affect costs and to predict breast cancer costs with known patient factors 11–13 . All data analysis was conducted separately for stage I–III and stage IV cancers.…”
Section: Methodsmentioning
confidence: 99%
“…Healthcare expenditure data have mixed distributions, characterized by a disproportionate proportion of zero‐cost observations (nonusers) and a right‐skewed distribution 10 . Therefore, we introduced a two‐part model to identify what factors affect costs and to predict breast cancer costs with known patient factors 11–13 . All data analysis was conducted separately for stage I–III and stage IV cancers.…”
Section: Methodsmentioning
confidence: 99%
“…Handling such data using linear regression without taking cognisance of the many zeros could pose challenges regarding the difficulties in deriving error terms that are normal ( Belotti et al., 2015 ; Carboni, 2012 ). We used two approaches in the literature to address the problem: inverse hyperbolic sine transformation of the dependent variable ( Bellemare and Wichman, 2019 ; Burbidge et al., 1988 ; Lavin et al., 2017 ; MacKinnon and Magee, 1990 ; Pence, 2006 ) and two-part mixture models ( Cragg, 1971 ; Ciminata et al., 2020 ; Duan et al., 1984 ; Lee et al., 2019 ; Mihaylova et al., 2011 ).…”
Section: Methodsmentioning
confidence: 99%
“…The two-part model requires fitting a binary choice model for the probability of observing a positive-versus-zero outcome. Subsequently, based on a positive outcome, a regression model is estimated for the positive outcome ( Belotti et al., 2015 ; Ciminata et al., 2020 ; Zhao et al., 2020 ). Following Lee et al.…”
Section: Methodsmentioning
confidence: 99%
“…Multimorbidity is defined as the coexistence of two or more chronic diseases in a person ( 2 , 3 ), with global prevalence ranging from 12.9% (the whole population) to 95.1% (those aged 65 years and older) ( 4 ), while the prevalence in low-and-middle-income countries (LMICs) is on the rise ( 5 7 ). Multimorbidity is closely related to disability, decreased quality of life, premature death, unplanned hospitalizations, and increased consumption of health resources, which imposes a heavy strain on individuals and healthcare systems ( 7 , 8 ).…”
Section: Introductionmentioning
confidence: 99%