2021
DOI: 10.1016/j.snb.2020.129159
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A two-photon fluorescent probe based on link-anthocyanin for detecting cysteine in nucleoli and lysosomes

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Cited by 15 publications
(5 citation statements)
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“…The probe had a ratiometric recognition of GSH in PBS/MeCN (from no fluorescence to blue and yellow fluorescence), along with a detection limit of 2.6 μmol/L, but this probe was subject to a certain interference from Hcy and Cys because of the lack of selectivity in the cleavage of disulfide bonds. Biothiols can also undergo addition or substitution reactions in the presence of some specific recognition groups, such as 2,4-dinitrobenzenesulfonyl, [52] acrylate, [53] nitrobenzoxazole, [54] etc. The carbon atoms, which are connected to sulfonyl or ether bonds on the benzene ring of 2,4-dinitrobenzenesulfonyl or nitrobenzoxazole, have strong electron-withdrawing properties.…”
Section: Fluorescence Sensors For Biological Moleculesmentioning
confidence: 99%
“…The probe had a ratiometric recognition of GSH in PBS/MeCN (from no fluorescence to blue and yellow fluorescence), along with a detection limit of 2.6 μmol/L, but this probe was subject to a certain interference from Hcy and Cys because of the lack of selectivity in the cleavage of disulfide bonds. Biothiols can also undergo addition or substitution reactions in the presence of some specific recognition groups, such as 2,4-dinitrobenzenesulfonyl, [52] acrylate, [53] nitrobenzoxazole, [54] etc. The carbon atoms, which are connected to sulfonyl or ether bonds on the benzene ring of 2,4-dinitrobenzenesulfonyl or nitrobenzoxazole, have strong electron-withdrawing properties.…”
Section: Fluorescence Sensors For Biological Moleculesmentioning
confidence: 99%
“…3, the addition cyclization reaction between Cys and acrylate releases a fluorophore resulting in fluorescence, and the 1 H NMR spectrum showed that there are three distinct protons in TIFC (respectively labeled as H a , H b and H c ) but not in TIFC-OH, indicating that the addition of Cys will cause the disappearance of these proton signals and the appearance of new proton signals, and revealing that Cys undergoes Michael addition reaction with acrylate and then undergoes autonomous intramolecular cyclization. There have been numerous studies describing the Michael addition reaction mechanisms, 18,37 and have not been discussed in this study.…”
Section: Detection Mechanism Researchmentioning
confidence: 99%
“…Compared with common analysis methods such as fluorescent spectroscopy, potentiometry, and high performance liquid chromatography (HPLC), 9,[12][13][14][15][16][17][18] which are cumbersome and less used for the intracellular detection of biological thiols, fluorescent probes have attracted increasing attention in this field because of their simple operation, high resolution, high sensitivity, real-time detection, penetrability and noninvasiveness. [19][20][21][22][23][24][25][26] At present, more and more small molecule fluorescent probes and nanosensors have been designed, synthesized, and extensively used in the detection of biological thiols.…”
Section: Introductionmentioning
confidence: 99%
“…Over the past few decades, various luminescent chromophores [23] and luminescent nano-assemblies [24] have been synthesized and constructed, and are widely used in cell imaging. Typical synthetic luminescent probes, especially nearinfrared (NIR) dyes, are anthocyanin, [25] boron fluoride (BODIPY), [26] rhodamine, [27] porphyrin, [28] phthalocyanine, [29] fluorescein, [30] and oxazine. [31] The key drawback of organic molecule-based fluorescent probes is that when the concen-tration of dyes increases, the fluorescence intensity is greatly quenched (aggregation-caused quenching (ACQ) effect).…”
Section: Introductionmentioning
confidence: 99%