A two-pronged strategy to alleviate tumor hypoxia and potentiate photodynamic therapy by mild hyperthermia

Abstract

The application of photodynamic therapy (PDT) is limited by tumor hypoxia. To overcome hypoxia, catalase-like nanozymes are often used to catalyze endogenous H2O2 enriched in tumor tissues to O2. Nonetheless,...

Nanotechnological strategies to increase the oxygen content of the tumor

“…The heat generated by CuS after near infrared laser irradiation could convert the liquid PFP into a gaseous state and release it from the cavity of the HMON to further promote the release of oxygen and promote the diffusion of oxygen in the tumor, thereby overcoming the radiotherapy tolerance of the tumor. In addition, photothermal therapy combined with other treatment methods also proves that mild phototherapy can indeed lead to the improvement of blood supply and hypoxia in tumors, thus making tumors more sensitive to treatments ( Li et al, 2020b ; Li et al, 2022a ; Zhang et al, 2022c ).…”

Modulating tumor mechanics with nanomedicine for cancer therapy

“…This conclusion is corroborated by other researchers. 40,41 Nanomedicines with simple structure and components have a higher chance of clinical translation and bedside application. However, molecular understanding of nanomedicine-mediated mild hyperthermia on TMME regulation warrants further investigations.…”

“…20 To that end, several clinical treatments, including radiation therapy, 21–25 hyperbaric oxygen therapy, 26–30 and enzymatic therapy 31–33 have been leveraged to tackle the physical obstacles and augment nanomedicine antitumor efficacy. Furthermore, multifarious nanomedicines capable of interrupting the TMME by means of photodynamic therapy 34–36 and photothermal therapy 37–46 have been prepared and tested in preclinical studies. Modulating tumor mechanics with therapeutic agents is emerging as a new research direction for cancer nanomedicines, 47–49 and has become a hot topic in the field of cancer therapy in recent years.…”

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

“…However, the catalase activity may not be optimal for enough O 2 supply at body temperature to meet the rapid O 2 consumption of PDT. In order to treat tumor hypoxia, Zhang et al created hollow mesoporous Prussian blue NPs (Ce6@HMPB NPs), which have photothermal potential and temperature-sensitive catalase activity . In this system, the photothermal effect of Ce6@HMPB NPs can elevate the catalase activity of the nanoplatform for O 2 generation.…”

“…In order to treat tumor hypoxia, Zhang et al created hollow mesoporous Prussian blue NPs (Ce6@ HMPB NPs), which have photothermal potential and temperature-sensitive catalase activity. 243 In this system, the photothermal effect of Ce6@HMPB NPs can elevate the catalase activity of the nanoplatform for O 2 generation. Meanwhile, mild hyperthermia can reduce CAFs and induced ECM degradation, which relieves the solid stress of tumor tissues and normalizes the tumor vasculature, thus benefiting the external supplementation of O 2 to tumors.…”