A two-SNP IL-6 promoter haplotype is associated with increased lung cancer risk

Chen, Jun; Liu, Rengyun; Yang, Lei; Zhao, Jun; Zhao, Xueying; Lu, Daru; Yi, Nengjun; Han, Baohui; Chen, Xiaofeng; Zhang, Kui; He, Jun; Li, Zhe; Zhou, Yifeng; Pasche, Boris; Li, Xiangdong; Zhang, Hongtao

doi:10.1007/s00432-012-1314-z

Cited by 34 publications

(21 citation statements)

References 51 publications

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“…Among these SNPs, rs1524107, and rs2066992 were identified that have association with EC risk. Rs1524107 was identified that has associations with several disease, including rheumatoid arthritis (Li et al, ), major depressive disorder (Chen, Wu, Zhao, Fan, & Fang, ), Alzheimer's disease (Chen et al, ), adult‐onset asthma (Lajunen, Jaakkola, & Jaakkola, ), lung cancer (Chen et al, ) et al, however, we did not found any reports association with EC risk in Chinese han population. For rs2066992, Juo et al, researched the rs2066992 and endometriosis risk, however, there is no significance.…”

Section: Discussioncontrasting

confidence: 55%

Genetics of IL6 polymorphisms: Case–control study of the risk of endometrial cancer

Cai¹,

Cui

Niu

et al. 2019

Molec Gen & Gen Med

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Background Endometrial cancer is the most common gynaecological malignancy. Cytokines gene may be important in endometrial cancer development. This study sought to investigate whether the IL4, IL6 two gene genetic variants were associated with susceptibility to endometrial cancer (EC) in Hainan Chinese Han women by a hospital‐based study. Methods The genetic polymorphisms for IL4 and IL6 were analyzed by Agena MassARRAY method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression. Results We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09–2.37, p = 1.55 × 10−2), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11–4.53, p = 3.13 × 10−9). However, for IL4 gene, no associations emerged the SNP and EC risk. Conclusion This study demonstrated that IL6 gene polymorphisms are significantly associated with increased EC susceptibility in Hainan Chinese Han women.

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Section: Discussioncontrasting

confidence: 55%

Genetics of IL6 polymorphisms: Case–control study of the risk of endometrial cancer

Cai¹,

Cui

Niu

et al. 2019

Molec Gen & Gen Med

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“…Chen et al . showed that a two-single-nucleotide polymorphism (SNP) CC (-6331C and -572C) IL-6 promoter haplotype was significantly more common among cases than among controls in both groups, indicating this haplotype is associated with increased lung cancer risk [ 25 ]. Therefore, comprehensive haplotype-based or multiple SNP-based strategies may provide more precise information on the genetic contribution of TNF-α or IL-6 to cancer etiology in the future [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Meta-analysis of the associations between TNF-α or IL-6 gene polymorphisms and susceptibility to lung cancer

Zhou

Zhang

et al. 2015

Eur J Med Res

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BackgroundSeveral studies have indicated an association between tumor necrosis factor-alpha (TNF-α) or interleukin (IL)-6 gene polymorphisms and lung cancer risk. However, the conclusions remain controversial.MethodsAn English literature screening about case-control trials with regard to TNF-α (-308G/A) or IL-6 (174G/C) polymorphisms and lung cancer susceptibility was performed on PubMed, EMBASE, and EBSCO until November 2012. The pooled odds ratio (OR) and 95% confidence intervals (CI) were calculated using STATA 11.0. Sensitivity analysis was performed by sequential omission of individual studies. Publication bias was evaluated by Egger’s linear regression test and funnel plots.ResultsEight eligible studies, including 1,690 patients and 1,974 controls, were identified in this meta-analysis. Compared with the control, no significant association was revealed between TNF-α-308G/A (GG + GC vs. CC: OR = 1.10, 95% CI: 0.73 to 1.64; GG vs. GC + CC: OR = 1.02, 95% CI: 0.81 to 1.27; GC vs. CC: OR = 1.13, 95% CI: 0.73 to 1.77; GG vs. CC: OR = 1.04, 95% CI: 0.80 to 1.36; G vs. C: OR = 1.03, 95% CI: 0.90 to 1.18) or IL-6 174G/C (GG + GC vs. CC: OR = 1.10, 95% CI: 0.73 to 1.64; GG vs. GC + CC: OR = 1.02, 95% CI: 0.81 to 1.27; GC vs. CC: OR = 1.13, 95% CI: 0.73 to 1.77; GG vs. CC: OR = 1.04, 95% CI: 0.80 to 1.36; G vs. C: OR = 1.03, 95% CI: 0.90 to 1.18) and lung cancer risk. The pooled OR remained unchanged after removing the maximum-weight study and no publication bias was observed.ConclusionsThe study raises the possibility of no correlation between the polymorphisms of the two genes and lung cancer susceptibility. However, further researches with large-sample or subgroup analyses are necessary to validate the conclusions.

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“…Construction of luciferase reporter gene plasmids was performed as previously described (Chen et al, 2013). A 751-bp sequence of IL-6 gene was amplified from the genomic DNA of healthy volunteers homozygous for the -572 C allele.…”

Section: Luciferase Reporter Gene Assaymentioning

confidence: 99%

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

Zhu¹,

Li²,

Li³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay (ELISA). Results indicated that when the IL-6 -572 CC homozygote genotype was used as the reference group, the GG genotype was found to be associated with a significantly increased risk of KS (GG vs CC: OR = 2.097, 95%CI = 1.100-3.995, P = 0.025). When the IL-6 -572 C allele was used as the reference group, the G allele was found to be associated with significantly increased risk of KS (G vs C: OR = 1.317, 95%CI = 1.002-1.730, P = 0.048). Furthermore, we observed a marked 2 X.J. Zhu et al. Genetics and Molecular Research 16 (2): gmr16029110 increase in serum IL-6 levels in KS patients with GG genotypes when compared to KS patients harboring the CC genotype. In conclusion, our results suggest that IL-6 gene polymorphism was associated with keloid scars in the southeastern Chinese Han population.

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A two-SNP IL-6 promoter haplotype is associated with increased lung cancer risk

Cited by 34 publications

References 51 publications

Genetics of IL6 polymorphisms: Case–control study of the risk of endometrial cancer

Genetics of IL6 polymorphisms: Case–control study of the risk of endometrial cancer

RETRACTED ARTICLE: Meta-analysis of the associations between TNF-α or IL-6 gene polymorphisms and susceptibility to lung cancer

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

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