High voltage gain DC-DC boost converters are widely used in grid-connected applications through integration with the Renewable Energy Sources (RESs). Photovoltaic (PV) arrays or Fuel Cells (FCs) generate a limited value of the DC voltages and then for high power and high voltage applications, at the first stage, these voltages should be increased. This study presents a high gain, single-switched, and efficient DC-DC boost converter using the switched-capacitor and switched-inductor cells. These blocks easily can enhance the voltage and present an input current with the least values of the ripples. This will be done through replacing the location of the input inductors and by applying a switched-inductor block. Magnetizing in parallel and demagnetizing in series for the inductors present the smaller input current stresses. A single switch is used for the proposed boost converter that directly decreases the complexity of the control circuit for obtaining a fixed DC voltage at the output side for flexible input voltages or loads. More voltages will be presented by the used switched-capacitor cell simply by adding several diodes and capacitors. A deep and detailed mathematical analysis will be presented for continuous (CCM) and discontinuous conduction modes (DCM) and a 200 W laboratory-scaled prototype is presented. The results of the hardware tests confirm the correctness of the theoretical analysis and simulation results.INDEX TERMS DC-DC boost converter, switched-capacitor, switched-inductor, continuous conduction mode (CCM), discontinuous conduction mode (DCM).