A two-step ligand exchange reaction generates highly water-dispersed magnetic nanoparticles for biomedical applications

Hatakeyama, Mamoru; Kishi, Hiroshi; Kita, Yoshinori; Imai, Kensuke; Nishio, Kosuke; Karasawa, Satoki; Masaike, Yuka; Sakamoto, Satoshi; Sandhu, Adarsh; Tanimoto, Akihiro; Gomi, Tatsuya; Kohda, Ehiichi; Abe, Masanori; Handa, Hiroshi

doi:10.1039/c0jm04381h

Cited by 47 publications

(39 citation statements)

References 29 publications

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“…The vibration of the -SH group present two peaks at 2664 and 2571 cm -1 (slightly observed in 3-MPA-coated SPION). The -COOH group has a stretching vibration of C=O at 1714 cm -1 and the stretching vibration for C-O at 1267 cm -1 [34,35]. Finally, a band at 951 cm -1 is attributed to O-H out of plane wagging [36].…”

Section: Characterization Of Adsorbent Materialsmentioning

confidence: 99%

Arsenate removal with 3-mercaptopropanoic acid-coated superparamagnetic iron oxide nanoparticles

Morillo

Uheida

Pérez

et al. 2015

Journal of Colloid and Interface Science

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In the present work, superparamagnetic iron oxide nanoparticles (SPION) surface-coated with 3-mercaptopropanoic acid (3-MPA) were prepared and their feasibility for the removal of arsenate from dilute aqueous solutions was demonstrated. The synthesized 3-MPA-coated SPION was characterized using transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and Fourier transform infra-red spectrometry (FTIR). Separation efficiency of the coated nanoparticles and the equilibrium isotherm of arsenate adsorption were investigated. The obtained results reveal the arsenate adsorption to be highly pH-dependent, and the maximum adsorption was attained in less than 60 minutes. The resulting increase of 3-MPA-coated SPION adsorption capacity to twice the adsorption capacity of SPION alone under the same conditions is attributed to the increase of active adsorption sites. An adsorption reaction is proposed. On the other hand, efficient recovery of arsenate from the loaded nanoparticles was achieved using nitric acid (HNO 3 ) solution, which also provides a concentration over the original arsenate solution. HIGHLIGHTS• Feasibility of using SPION modified with 3MPA for the removal of As(V).• The adsorbent system results in an effective sorption for selective As(V) removal.• The adsorption capacity for As(V) is higher comparing with other adsorbent systems.• Adsorption mechanism has been proposed as the most suitable considering the results.

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Section: Characterization Of Adsorbent Materialsmentioning

confidence: 99%

Arsenate removal with 3-mercaptopropanoic acid-coated superparamagnetic iron oxide nanoparticles

Morillo

Uheida

Pérez

et al. 2015

Journal of Colloid and Interface Science

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“…[6] As-synthesised cubic iron oxide NPs in toluene (10 mg mL À1 ) were mixed with 1 mL DMSA (0.25 M) in DMSO. The mixture was sonicated at 50-60 Hz for ,3-4 h until precipitation occurred (this indicated that the organic ligands were replaced by DMSA).…”

Section: Ligand Exchangementioning

confidence: 99%

“…However, most applications require the particles to be dispersed in an aqueous media. [3,6,8,23] In the past, much work has been dedicated to prepare MNPs that can be dispersed in water. For example, amphiphilic polymer coatings, [3,8] crosslinked dextran coatings, [24][25][26] coordination of surface ligands with amphiphilic polymers through van der Waals interactions, [27] and silica surface coatings [28] have been explored.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Phase Transfer of Monodisperse Iron Oxide (Fe3O4) Nanocubes

Dewi¹,

Skinner²,

Nann³

2014

Aust. J. Chem.

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Cube-shaped magnetic iron oxide nanoparticles were synthesised and studied with the aim to achieve superior magnetic properties. This study describes a straightforward and simple synthesis method for preparing monodisperse 11-14-nm superparamagnetic iron oxide nanocubes via an 'effective monomer' growth mechanism. The as-synthesised nanoparticles are insoluble in water. However, substitution of the non-polar ligands of the particles using a new method that involved an ionic compound generated colloidally stable and water dispersible cube-shaped particles with a very small hydrodynamic diameter. The cubes displayed superior magnetic properties over spherical particles.

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“…Citric acid and surfactants are frequently used to stabilize IONPs in aqueous solutions (28–30), but these stabilizers often cause problems. For example, although citric acid forms a stable chelate with Fe 3 O 4 iron oxide, it is not sufficient to prevent agglomeration and precipitation in the presence of multivalent counter ions (magnesium or calcium) and serum proteins (31–34). Surfactants, typically prepared from multivalent polymers, have been also developed to stabilize IONPs in vivo, yet they can get detached from IONPs due to an unclear mechanism by which ligand exchange occurs in metal chelates (35–37).…”

Section: Introductionmentioning

confidence: 99%

Block Copolymer Cross-Linked Nanoassemblies Improve Particle Stability and Biocompatibility of Superparamagnetic Iron Oxide Nanoparticles

Scott

Hardy

et al. 2012

Pharm Res

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Purpose To develop cross-linked nanoassemblies (CNAs) as carriers for superparamagnetic iron oxide nanoparticles (IONPs). Methods Ferric and ferrous ions were co-precipitated inside core-shell type nanoparticles prepared by cross-linking poly(ethylene glycol)-poly(aspartate) block copolymers to prepare CNAs entrapping Fe3O4 IONPs (CNA-IONPs). Particle stability and biocompatibility of CNA-IONPs were characterized in comparison to citrate-coated Fe3O4 IONPs (Citrate-IONPs). Results CNA-IONPs, approximately 30 nm in diameter, showed no precipitation in water, PBS, or a cell culture medium after 3 or 30 h, at 22, 37, and 43 °C, and 1, 2.5, and 5 mg/mL, whereas Citrate-IONPs agglomerated rapidly (> 400 nm) in all aqueous media tested. No cytotoxicity was observed in a mouse brain endothelial-derived cell line (bEnd.3) exposed to CNA-IONPs up to 10 mg/mL for 30 h. Citrate-IONPs (> 0.05 mg/mL) reduced cell viability after 3 h. CNA-IONPs retained the superparamagnetic properties of entrapped IONPs, enhancing T2-weighted magnetic resonance images (MRI) at 0.02 mg/mL, and generating heat at a mild hyperthermic level (40 ~ 42 °C) with an alternating magnetic field (AMF). Conclusion Compared to citric acid coating, CNAs with a cross-linked anionic core improved particle stability and biocompatibility of IONPs, which would be beneficial for future MRI and AMF-induced remote hyperthermia applications.

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A two-step ligand exchange reaction generates highly water-dispersed magnetic nanoparticles for biomedical applications

Cited by 47 publications

References 29 publications

Arsenate removal with 3-mercaptopropanoic acid-coated superparamagnetic iron oxide nanoparticles

Arsenate removal with 3-mercaptopropanoic acid-coated superparamagnetic iron oxide nanoparticles

Synthesis and Phase Transfer of Monodisperse Iron Oxide (Fe3O4) Nanocubes

Block Copolymer Cross-Linked Nanoassemblies Improve Particle Stability and Biocompatibility of Superparamagnetic Iron Oxide Nanoparticles

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