A two-step synthesis of new macrobicyclic aza-ligands starting from “trans”dioxocyclam as diprotected macrocycle

Denat, Franck; Lacour, Sylvie; Brandès, Stéphane; Guilard, Roger

doi:10.1016/s0040-4039(97)00944-1

Cited by 38 publications

(20 citation statements)

References 22 publications

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“…[ Cryptands comprising of two or more cycles containing O, S or N atoms coupled by ethylene bridges constitute a class of macrocyclic compounds. [95][96][97] They form stable complexes with alkali, alkaline earth, and some other metal cations. The former are cryptates, in which a metal ion is strongly shielded by the surrounding atoms from solvent and counterion species.…”

Section: Macroheterocycles Functionalization Accompanied By Preservatmentioning

confidence: 99%

Functionalisation of Macroheterocycles with Preserving and Changing Their Sizes

Ishmuratov¹,

Yakovleva²,

Выдрина³

et al. 2017

MHC

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Section: Macroheterocycles Functionalization Accompanied By Preservatmentioning

confidence: 99%

Functionalisation of Macroheterocycles with Preserving and Changing Their Sizes

Ishmuratov¹,

Yakovleva²,

Выдрина³

et al. 2017

MHC

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“…117 Regioselective disubstitution of cyclen can be performed by using group VI metal carbonyls such as (Cr(CO) 6 or Mo(CO) 6 ) as a protecting group. 99,119 This trans "autodiprotected" cyclam is prepared in large scale and allows for further substitution by any functional group which survives the relatively mild conditions necessary for reduction of the two amide groups (BH 3 /THF). Reaction of an alkyl bromide leads only to a monosubstituted derivative while trans dialkylation is observed when an alkyl iodide is used.…”

Section: N-substitution Of Protected Macrocyclesmentioning

confidence: 99%

Strategies for the Regioselective N-Functionalization of Tetraazacycloalkanes. From Cyclam and Cyclen Towards More Sophisticated Molecules

2000

Synlett

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Different approaches for the selective N-substitution of tetraazacycloalkanes and more specifically cyclam and cyclen are reported. The N-functionalization can be performed either before or after cyclization, and various protecting groups might be used to discriminate one, two or three nitrogen atoms. For example, tert-butyloxycarbonyl (Boc) appears to be a very convenient protecting group since it can be removed under mild conditions. trans-Disubstituted macrocycles are easily prepared by using trans-dioxotetraazacycloalkanes or a cyclam containing a bisaminal moiety as the starting material. These precursors allow for the synthesis of preorganized molecules such as cryptands and macrotricycles in relatively large scale and in very decent yields.

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“…There has been a great deal of interest in the synthesis of free and substituted polyazamacrocycles due to their wide range of applications 3. It has been demonstrated that macrocyclic ligands containing nitrogen and sulfur as donor atoms can behave as highly selective complexing agents for transition metal cations and heavy metal ions 4, 5…”

Section: Introductionmentioning

confidence: 99%

Synthesis of functionalized polymeric adsorbent selective to cobalt

Ghag

Mahanwar

2011

J of Applied Polymer Sci

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Amino derivative of chloromethylated polystyrene resin was synthesized and functionalized by 1,10-phenanthroline (1,10-Phen) to yield a novel adsorbent, namely 4-methylamino-[N,N-bis(2,2 0 )-1,10-phenanthroline] polystyrene (4-MABPPS). The complete development of novel adsorbent along with its characterization is described in detail. The adsorption ability and selectivity of 4-MABPPS were investigated for cobalt and zirconium ions so as to efficiently separate cobalt ion impurities from zircalloy cladding material of nuclear reactors. The experimental results showed selective uptake of cobalt by the adsorbent in the presence of zirconium.

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A two-step synthesis of new macrobicyclic aza-ligands starting from “trans”dioxocyclam as diprotected macrocycle

Cited by 38 publications

References 22 publications

Functionalisation of Macroheterocycles with Preserving and Changing Their Sizes

Functionalisation of Macroheterocycles with Preserving and Changing Their Sizes

Strategies for the Regioselective N-Functionalization of Tetraazacycloalkanes. From Cyclam and Cyclen Towards More Sophisticated Molecules

Synthesis of functionalized polymeric adsorbent selective to cobalt

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