A two-year inhalation study of the carcinogenic potential of ethylene oxide in fischer 344 rats*1

Snellings, William M.

doi:10.1016/0041-008x(84)90081-4

Cited by 139 publications

(50 citation statements)

References 21 publications

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“…of primary mesotheliomas in Fischer 344 rats were similar to those of asbestos-induced mesotheliomas in this species. Our detailed histologic and electron microscopic findings of the tumors, as those of others (4,13,20,24,29), were quite similar to those induced by asbestos. These results indicate that morphological characteristics of mesotheliomas are the same, irrespective of whether the tumors are induced or spontaneous.…”

Section: Discussionsupporting

confidence: 65%

“…There are numerous reports concerning the histogenesis and detailed morphology of asbestosinduced mesotheliomas in rats by means of light and electron microscopy (8,9,14,23,32), but few reports are available for those spontaneous, although Gould (1 2) described briefly histological findings and histogenesis ofthe tumors. On the other hand, there are several reports that the incidence of those mesotheliomas was increased in Fischer 344 rats by oral administration or by inhalation exposure of some chemicals (5, 6,15,17,24).…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Mesotheliomas in Fischer Rats—A Histological and Electron Microscopic Study

1987

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A E S T R A~Seventeen mesotheliomas from 395 untreated male Fischer 344/DuCrj rats were studied by light and electron microscopy to define the morphological characteristics of the tumors. In 16 out of 17 rats, mesotheliomas were observed in the abdominal and/or scrota1 sac, and the other one was localized on the pleura. Grossly, tumors were yellow-brown with various-sized multiple modules growing irregularly over the surface of the serosa. Microscopically, they varied from complex papillary to sessile nodular growths. Tumor cells were cuboidal to polygonal with round to oval nuclei, and were sometimes arranged in tubule-like structures. Occasionally, the cells contained Mowry's colloidal iron positive materials, which were negative following prior incubation with hyaluronidase. Furthermore, intracellular keratins were detected using the peroxidaseantiperoxidase method. Ultrastructural features of tumor cells included numerous microvilli, a basement membrane, junctional complexes, abundant cytofilaments, dilated rough surfaced endoplasmic reticulum cisternae, and a well-developed Golgi apparatus. The morphological characteristics of these tumors in Fischer 344 rats were consistent with those in humans and with experimentally induced counterparts in rats. The histogenesis of these tumors and the variability in their incidence following oral administration of chemical carcinogens is discussed.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Spontaneous Mesotheliomas in Fischer Rats—A Histological and Electron Microscopic Study

1987

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“…9 Chemical agents such as ethylene oxide or hydrogen peroxide for sterilization are limited because of their toxicity to eukaryotic cells. 10,11 In clinical applications, a successful decolonisation of MRSA strongly depends on the compliance of the patients and the treatment protocol used. Such a protocol usually consists of a triple therapy for five days of daily nasal mupirocin ointment, chlorhexidine mouth rinse, and full-body wash with chlorhexidine soap.…”

Section: Introductionmentioning

confidence: 99%

Dirty hands: photodynamic killing of human pathogens like EHEC, MRSA and Candida within seconds

Eichner

Gonzales

Felgenträger

et al. 2012

Photochem Photobiol Sci

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aHand hygiene is one of the most important interventions for reducing transmission of nosocomial lifethreatening microorganisms, like methicillin resistant Staphylococcus aureus (MRSA), enterohemorrhagic Escherichia coli (EHEC) or Candida albicans. All three pathogens have become a leading cause of infections in hospitals. Especially EHEC is causing severe diarrhoea and, in a small percentage of cases, haemolytic-uremic syndrome (HUS) as reported for E. coli 104:H4 in Germany 2011. We revealed the possibility to inactivate very fast and efficiently MRSA, EHEC and C. albicans using the photodynamic approach.MRSA, EHEC and C. albicans were incubated in vitro with different concentrations of TMPyP for 10 s and illuminated with visible light (50 mW cm TMPyP on ex vivo porcine skin, fluorescence microscopy of histology showed that the photosensitizer was exclusively localized in the stratum corneum regardless of the incubation time. TMPyP exhibited a fast and very effective killing rate of life-threatening pathogens within a couple of seconds that encourages further testing in an in vivo setting. Being fast and effective, antimicrobial photodynamic applications might become acceptable as a tool for hand hygiene procedures and also in other skin areas.

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“…It is mutagenic in bacteria, plants, fungi, and insects (22). Ethylene oxide administered to rats by inhalation increased the incidence of mononuclear-cell leukemia (40). Epidemiologic studies of two occupationally exposed populations in Sweden are suggestive of an association between ethylene oxide and leukemia (15)…”

Section: Ethylene Oxidementioning

confidence: 99%

Current trends in the biological monitoring of exposure to carcinogens.

Vainio¹

1985

Scand J Work Environ Health

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A two-year inhalation study of the carcinogenic potential of ethylene oxide in fischer 344 rats*1

Cited by 139 publications

References 21 publications

Spontaneous Mesotheliomas in Fischer Rats—A Histological and Electron Microscopic Study

Spontaneous Mesotheliomas in Fischer Rats—A Histological and Electron Microscopic Study

Dirty hands: photodynamic killing of human pathogens like EHEC, MRSA and Candida within seconds

Current trends in the biological monitoring of exposure to carcinogens.

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