Abstract. We introduce an invariant of tangles in Khovanov homology by considering a natural inverse system of Khovanov homology groups. As application, we derive an invariant of strongly invertible knots; this invariant takes the form of a graded vector space that vanishes if and only if the strongly invertible knot is trivial. While closely tied to Khovanov homology -and hence the Jones polynomial -we observe that this new invariant detects non-amphicheirality in subtle cases where Khovanov homology fails to do so. In fact, we exhibit examples of knots that are not distinguished by Khovanov homology but, owing to the presence of a strong inversion, may be distinguished using our invariant. This work suggests a strengthened relationship between Khovanov homology and Heegaard Floer homology by way of two-fold branched covers that we formulate in a series of conjectures. There are two features common to each of these applications. First, the quantity extracted from Khovanov homology is an integer (a particular grading [28,35,37], a count of a collection of gradings [47], or a dimension count [21]); and second, the quantity measured is not one that can be extracted from the Jones polynomial -additional structure in Khovanov homology is essential in each case. The latter points to a clear advantage of