A typical Kawasaki syndrome in COVID-19 infection: a case report of a multisystem inflammatory syndrome in a child (MIS-C)

Abstract

The emergence of COVID-19 by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) in 2019 has seen evolving data reporting infrequent infection in children and mostly mild disease for children who contract the infection. A severe form of COVID-19 in children recently reported in Europe and North America describes a multisystem inflammation syndrome in children (MIS-C), presenting as toxic-shock-like and Kawasaki-like syndromes. Data on MIS-C in Africa is being documented with recent reports from South Africa and Nigeria in black children, but information on MIS-C in Ghana is yet to be characterized. We report the first case of multisystem inflammatory syndrome in a child who tested PCR positive to SARS-CoV2 in a tertiary hospital in Ghana. The case describes a 10-year-old boy who reported Kawasaki-like syndrome without shock but with moderate respiratory distress requiring supportive acute care without the need for intensive care.

Epidemiology, clinical profiles, and prognostic value of COVID‐19‐related cutaneous manifestations in African populations: a rapid narrative review

“…Table 1 summarizes the demographics, clinical presentations, and topography of COVID‐19‐related cutaneous manifestations. Several studies in African populations have reported MIS‐C and MIS‐A or Kawasaki‐like disease 25–27,67–81 . Figure 3 represents 47.5% (115/242) of MIS‐C and MIS‐A cases reported in nine published African studies.…”

“…Several studies in African populations have reported MIS-C and MIS-A or Kawasaki-like disease. [25][26][27][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81] published African studies. MIS was more common in men between the ages of 2.3 and 51 years.…”

“…Figure 3 represents 47.5% (115/242) of MIS‐C and MIS‐A cases reported in nine published African studies. MIS was more common in men between the ages of 2.3 and 51 years 25–27,67–81 . Polymorphous maculopapular eruptions on the trunk and flexural areas, acral erythema, extremity swelling, desquamation, mucositis, and fissured lips are all examples of MIS dermatological lesions 25–27,67–81 .…”

“…[25][26][27][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81] Polymorphous maculopapular eruptions on the trunk and flexural areas, acral erythema, extremity swelling, desquamation, mucositis, and fissured lips are all examples of MIS dermatological lesions. [25][26][27][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81] MIS lesions were mostly generalized or on the face, upper limbs, trunks, oral, hands, feet, palmar, and plantar surfaces in African populations (Table 1). Cases of MIS-C have been described as occurring after the peak of the epidemic and resembling both Kawasaki disease and toxic shock.…”