A U.K. multicentre audit of the assessment and management of psoriasis in children

Lam, Michael O.; Burden‐Teh, Esther; Taibjee, Saleem M.; Taylor, Aileen; Webster, Stephen B.; Dolman, S.; Jury, C. S.; Caruana, D. M.; Darné, S.; Carmichael, Andrew; Natarajan, S.; McPherson, Tess; Moore, A.; Katugampola, R.; Kalavala, M.; Al-Ismail, D.; Richards, Lorie; Jones, V. Faye; Syed, Samira; Glover, Mary; Hughes, Jenny; Anderson, Eric G.; Hughes, B.; Babakinejad, P.; Murphy, Ruth

doi:10.1111/bjd.13471

Cited by 8 publications

(14 citation statements)

References 5 publications

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“…Overall, 42 studies provided data on the sex distribution. Thirty‐three studies provided data on the percentage of the study population who were male . Twenty‐five of these 33 studies found that less than 50% of children with psoriasis were boys (range 35·9–49%).…”

Section: Resultsmentioning

confidence: 99%

The epidemiology of childhood psoriasis: a scoping review

et al. 2016

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What's already known about this topic?• The prevalence of psoriasis in children is lower than adults • A significant number of adults with psoriasis first developed skin disease in childhood • Genetic and environmental factors both play an important role in the onset of psoriasis • Disease associations, such as obesity, are an important area of current research activity What does this study add?• Mapping has shown a dramatic increase in the number of published studies over the past 25 years • Studies have been concentrated in Europe, Asia and North America; these studies have largely been case series or cross-sectional studies • Specific studies with standardised methodologies are needed to provide data on the frequency, clinical presentation, risk factors, associated diseases and long-term outcomes for child-onset psoriasis The Epidemiology of Childhood Psoriasis: A Scoping Review AbstractPsoriasis is an inflammatory non-communicable skin disease which affects both adults and children. At present the epidemiology and natural history of psoriasis are not widely understood. This scoping review aimed to map the existing literature on the epidemiology of child-onset psoriasis, provide a comprehensive, clinically useful review and identify research gaps for future studies.Search strategies were developed for OVID MEDLINE, OVID Embase, Google Scholar and hand-searching; 131 articles meeting the inclusion criteria and were mapped and 107 articles were included for data extraction.Over 25 years there has been a dramatic increase in the volume of published observational epidemiological studies on child-onset psoriasis. The majority were case series or crosssectional studies, concentrated in Europe, Asia and North America. The prevalence of childhood psoriasis was found to be higher in European countries, older children and females. Up to 48.8% of children had psoriasis in a first degree relative. The most frequent subtype was plaque psoriasis and initial site of presentation is most commonly scalp, limbs and trunk. Specific genetic differences have been found between the child-onset and adultonset populations. Case-control studies and cohort studies investigating risk factors for psoriasis onset, comorbidities and long-term health outcomes were extremely limited.The choice of study design and heterogeneity in methodology limit the validity and generalisability on the information, consistency of the results and comparability of the studies. Well-designed studies are needed to provide precise and consistent information about the frequency and clinical presentation, risk factors, associated diseases and longterm outcomes in child-onset psoriasis.

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Section: Resultsmentioning

confidence: 99%

The epidemiology of childhood psoriasis: a scoping review

et al. 2016

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“…In line with the recommendations for adults, methotrexate was the most frequently prescribed agent, followed by acitretin, which was prescribed in preference to ciclosporin. Fumaric acid esters are not licensed for treating adults in the U.K., and no children in this audit had received this treatment.…”

Section: Profile Of the Audit Population Detailing Pretreatment Screementioning

confidence: 85%

“…Dear Editor , A recent multicentre audit of current practice in the U.K. has revealed the routine use of conventional systemic agents to treat childhood psoriasis . The use of these agents has become routine despite licensing restrictions, and there is an absence of clear national guidance for systemic therapy in the treatment of psoriasis in children .…”

Section: Profile Of the Audit Population Detailing Pretreatment Screementioning

confidence: 99%

“…The National Institute for Health and Care Excellence (NICE) guidelines recommend the use of systemic agents in adult patients with extensive stable plaque psoriasis that is inadequately controlled using topical treatment and/or phototherapy . Methotrexate is advised as a first‐line agent, with ciclosporin recommended for patients who require rapid control.…”

Section: Profile Of the Audit Population Detailing Pretreatment Screementioning

confidence: 99%

“…Methotrexate is advised as a first‐line agent, with ciclosporin recommended for patients who require rapid control. Acitretin is suggested as a second‐line treatment . However, it is not known whether this is an appropriate therapeutic approach for treating children with psoriasis.…”

Section: Profile Of the Audit Population Detailing Pretreatment Screementioning

confidence: 99%

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