A unidirectional drug‐release Janus membrane based on hydrogen bonding barrier effect for preventing postoperative adhesion and promoting tissue repair

Wang, Qian; He, Min; Zhao, Weifeng; Zhao, Changsheng

doi:10.1002/viw.20230026

Cited by 4 publications

(1 citation statement)

References 73 publications

(47 reference statements)

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“…TA can interact with various materials via hydrogen bonding, π-π stacking, electrostatic interactions, coordination bonding, and hydrophobic interactions because of the phenol hydroxyl and phenyl groups in its chemical structure [ 21 , 22 , 23 ]. Thereby, through diverse interactions with bioactive factors, TA and its complexes have been utilized to control some bioactive factors to modulate cell response [ 24 ]. For example, Revzin et al reported that ultrathin TA-coated heparin microgels were able to capture about two times the basic fibroblast growth factor (BFGF) compared to bare heparin microgels.…”

Section: Introductionmentioning

confidence: 99%

In Situ Preparation of Tannic Acid-Modified Poly(N-isopropylacrylamide) Hydrogel Coatings for Boosting Cell Response

Xu,

Liu,

Liang

et al. 2024

Pharmaceutics

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The improvement of the capability of poly(N-isopropylacrylamide) (PNIPAAm) hydrogel coating in cell adhesion and detachment is critical to efficiently prepare cell sheets applied in cellular therapies and tissue engineering. To enhance cell response on the surface, the amine group-modified PNIPAAm (PNIPAAm-APTES) nanohydrogels were synthesized and deposited spontaneously on tannic acid (TA)-modified polyethylene (PE) plates. Subsequently, TA was introduced onto PNIPAAm-APTES nanohydrogels to fabricate coatings composed of TA-modified PNIPAAm-APTES (PNIPAAm-APTES-TA). Characterization techniques, including TEM, SEM, XPS, and UV-Vis spectroscopy, confirmed the effective deposition of hydrogels of PNIPAAm as well as the morphologies, content of chemical bonding-TA, and stability of various coatings. Importantly, the porous hydrogel coatings exhibited superhydrophilicity at 20 °C and thermo-responsive behavior. The fluorescence measurement demonstrated that the coating’s stability effectively regulated protein behavior, influencing cell response. Notably, cell response tests revealed that even without precise control over the chain length/thickness of PNIPAAm during synthesis, the coatings enhanced cell adhesion and detachment, facilitating efficient cell culture. This work represented a novel and facile approach to preparing bioactive PNIPAAm for cell culture.

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Section: Introductionmentioning

confidence: 99%

In Situ Preparation of Tannic Acid-Modified Poly(N-isopropylacrylamide) Hydrogel Coatings for Boosting Cell Response

Xu,

Liu,

Liang

et al. 2024

Pharmaceutics

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ADSCC‐CM‐Induced Keratin Hydrogel‐Based Bioactive Microneedle Patch Containing Triamcinolone Acetonide for the Treatment of Pathological Scar

Li,

Yi,

et al. 2024

Adv Funct Materials

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Pathological scars (PS) are involved in the excessive response of inflammation and overactivation of myofibroblasts. Herein, a novel microneedle (MN) patch based on the adipose‐derived stem cell concentrated conditioned medium (ADSCC‐CM) cross‐linked keratin hydrogel is developed to load triamcinolone acetonide (TA), thereby achieving the dual‐drug delivery of ADSCC‐CM and TA to simultaneously reduce the inflammation and guide myofibroblast behaviors. Results not only confirm the ability of ADSCC‐CM to drive the formation of keratin‐based hydrogel, but also verify the dual‐drug release capacities of the hydrogel‐developed MNs (TA@AC‐MN). Using human hyperplastic scar fibroblast (HSF), the combination of ADSCC‐CM and TA demonstrates a pronounced synergistic effect in mitigating the detrimental effects of the inflammatory microenvironment on HSFs, including suppressing the production of reactive oxygen species and attenuating the expression of inflammatory factors. Compared with the clinically used TA, TA@AC‐MN promotes scar biomimetic repair (i.e., optimizing the proportion of collagen and increasing the tissue tensile strength). This study demonstrates that TA@AC‐MN has the capacity to provide a self‐managing and minimally invasive therapeutic strategy for PS.

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Emerging Combination of Hydrogel and Electrochemical Biosensors

Huang,

Zhou,

et al. 2024

Small

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Electrochemical sensors are among the most promising technologies for biomarker research, with outstanding sensitivity, selectivity, and rapid response capabilities that make them important in medical diagnostics and prognosis. Recently, hydrogels have gained attention in the domain of electrochemical biosensors because of their superior biocompatibility, excellent adhesion, and ability to form conformal contact with diverse surfaces. These features provide distinct advantages, particularly in the advancement of wearable biosensors. This review examines the contemporary utilization of hydrogels in electrochemical sensing, explores strategies for optimization and prospective development trajectories, and highlights their distinctive advantages. The objective is to provide an exhaustive overview of the foundational principles of electrochemical sensing systems, analyze the compatibility of hydrogel properties with electrochemical methodologies, and propose potential healthcare applications to further illustrate their applicability. Despite significant advances in the development of hydrogel‐based electrochemical biosensors, challenges persist, such as improving material fatigue resistance, interfacial adhesion, and maintaining balanced water content across various environments. Overall, hydrogels have immense potential in flexible biosensors and provide exciting opportunities. However, resolving the current obstacles will necessitate additional research and development efforts.

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A unidirectional drug‐release Janus membrane based on hydrogen bonding barrier effect for preventing postoperative adhesion and promoting tissue repair

Cited by 4 publications

References 73 publications

In Situ Preparation of Tannic Acid-Modified Poly(N-isopropylacrylamide) Hydrogel Coatings for Boosting Cell Response

In Situ Preparation of Tannic Acid-Modified Poly(N-isopropylacrylamide) Hydrogel Coatings for Boosting Cell Response

ADSCC‐CM‐Induced Keratin Hydrogel‐Based Bioactive Microneedle Patch Containing Triamcinolone Acetonide for the Treatment of Pathological Scar

Emerging Combination of Hydrogel and Electrochemical Biosensors

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