Background-Creep-fatigue behavior is identified as the incorporated effects of fatigue and creep. One class of constitutive-based models attempts to evaluate creep and fatigue separately, but the interaction of fatigue and creep is neglected. Other models treat the damage as a single component, but the complex numerical structures that result are inconvenient for engineering application. The models derived through a curve-fitting method avoid these problems. However, the method of curving fitting cannot translate the numerical formulation to underlying physical mechanisms. Need-Therefore, there is a need to develop a new creep-fatigue formulation for metal that accommodates all relevant variables and where the relationships between them are consistent with physical mechanisms of fatigue and creep. Method-In the present work, the main dependencies and relationships for the unified creep-fatigue equation were presented through exploring what the literature says about the mechanisms. Outcomes-This shows that temperature, cyclic time and grain size have significant influences on creep-fatigue behavior, and the relationships between them (such as linear relation, logarithmical relation and power-law relation) are consistent with phenomena of diffusion creep and crack growth. Significantly, the numerical form of "1 − x" is presented to show the consumption of creep effect on fatigue capacity, and the introduction of the reference condition gives the threshold of creep effect. Originality-By this means, the unified creep-fatigue equation is linked to physical phenomena, where the influence of different dependencies on creep fatigue was explored and relationships shown in this equation were investigated in a microstructural level. Particularly, a physical explanation of the grain-size exponent via consideration of crack-growth planes was proposed.