1976
DOI: 10.1002/jbm.820100507
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A unified mathematical model for diffusion from drug–polymer composite tablets

Abstract: The derivation and experimental verification of a unified mathematical model for the estimation of drug release rate from drug-polymer composite tablets are presented. Cylindrical coordinates are utilized in the solution of the diffusion equation for a three-dimensional system. The model is applicable to tablets that range from the shape of a flat disk (radius greater than thickness) to that of a cylindrical rod (radius less than thickness). The general solution for the fraction of drug released at a time t is… Show more

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Cited by 83 publications
(67 citation statements)
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“…Such an analysis has been performed by Fu et al (1976) when no solubility limitations exist (A 0 < C s ). However, when there is an excess of drug (A 0 > C s ), the analytical treatment becomes considerably more involved.…”
Section: Matrix Geometrymentioning
confidence: 99%
“…Such an analysis has been performed by Fu et al (1976) when no solubility limitations exist (A 0 < C s ). However, when there is an excess of drug (A 0 > C s ), the analytical treatment becomes considerably more involved.…”
Section: Matrix Geometrymentioning
confidence: 99%
“…Solutions of Fick's second law can provide analytical relations for diffusion-controlled release curves obtained from devices of simple geometries [3,4], like slabs, spheres, or cylinders. Even though analytical results directly demonstrate the dependence of release characteristics on the parameters of the system, such solutions are not available when release mechanisms other than diffusion are significant, or when interparticle interactions are present.…”
Section: Introductionmentioning
confidence: 99%
“…The amount of release material could be described as a function of time using the relation expressed by Eq. (5), derived by Fu et al [35] M t M 1 ¼ 1 À …”
Section: Mutual Diffusionmentioning
confidence: 96%