A unified nomenclature for peroxisome biogenesis factors.

Regulation of the yeast SPS19 gene encoding peroxisomal 2,4‐dienoyl‐CoA reductase by the transcription factors Pip2p and Oaf1p: β‐oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium

“…This possibility was excluded by examining the ability of cells totally lacking peroxisomes to sporulate on this medium type. S. cerevisiae ⌬pex6 (formerly pas8; Voorn-Brouwer et al, 1993;Distel et al, 1996) mutant cells (yAG176) are devoid of peroxisomes showing no detectable peroxisomal structures. The homozygous ⌬pex6 diploid strain sporulated to wild-type levels of over 50% on solid medium containing acetate, and we therefore reasoned that, in S. cerevisiae, meiotic development takes place in the total absence of peroxisomal structures that may contain an intact ␤-oxidation system.…”

Clofibrate‐inducible, 28‐kDa peroxisomal integral membrane protein is encoded by PEX11

“…4). Pex11p may function as a peroxisome biogenesis regulator, possibly by interacting with other PEX proteins [2,3,18], including RING peroxins, Pex2p [13,22,46] and Pex12p [15,16,27], AAA family peroxins Pex1p [17,19,20] and Pex6p [14,25,26], a tetratricopeptide repeat (TPR) protein Pex5p (PTS1 receptor) [23,24,47], a WD motif protein Pex7p (PTS2 receptor) [48^50], and Pex13p (PTS1 receptor docking protein) presumed in mammals [51]. Functional role of Pex11p in peroxisome biogenesis in mammals remains to be investigated.…”

“…Peroxisomes are formed by division of preexisting peroxisomes after posttranslational import of newly synthesized proteins [1]. Genetic analysis of peroxisome-de¢cient mutants of yeast and mammalian cells have led to identi¢cation of a number of protein factors essential for peroxisome biogenesis [2,3]. Genetical heterogeneities comprising 12 complementation groups (CGs) have been identi¢ed in mammals, including humans [4^12].…”

Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import

“…Two distinct topogenic signals, peroxisomal targeting signal type 1 (PTS1) and PTS2 (16,40), direct proteins to the peroxisomal matrix. Genetic analyses of peroxisome-deficient mutants isolated from yeast and mammalian cells led to the identification of a number of proteins, known as peroxins, which are essential for peroxisome biogenesis (11,17,23,41). PEX5 and PEX7 encode the receptors for PTS1 and PTS2, respectively.…”