1998
DOI: 10.1097/00000478-199807000-00011
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A Unique Case of Cerebral Spleen

Abstract: We present the first case of cerebral splenosis, occurring in a 20-year-old man 15 years after posttraumatic splenectomy. He became symptomatic through seizures and was operated on for suspected meningioma of the right occipital pole. Histologic evaluation of the lesion revealed splenic tissue with matching immunohistochemical results. Because no penetrating head injuries were reported at the time of trauma, a hematogenous spread of splenic tissue has to be assumed.

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Cited by 75 publications
(41 citation statements)
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“…The cells can implant in any other location and take their blood supply from surrounding structures; splenosis has been reported as intrathoracic where there is a concomitant diaphragmatic injury or intrahepatic following an emergency splenectomy for trauma [4,5] . The pathogenesis is generally accepted to be mechanical implantation of cells, however there are case reports of intracranial splenic deposits from purported haematological spread [6] . Whilst it is assumed to be functional splenic tissue, splenosis usually does not have the histological appearance of normal spleen, nor does it form a hilum or a mature capsule.…”
Section: Discussionmentioning
confidence: 99%
“…The cells can implant in any other location and take their blood supply from surrounding structures; splenosis has been reported as intrathoracic where there is a concomitant diaphragmatic injury or intrahepatic following an emergency splenectomy for trauma [4,5] . The pathogenesis is generally accepted to be mechanical implantation of cells, however there are case reports of intracranial splenic deposits from purported haematological spread [6] . Whilst it is assumed to be functional splenic tissue, splenosis usually does not have the histological appearance of normal spleen, nor does it form a hilum or a mature capsule.…”
Section: Discussionmentioning
confidence: 99%
“…It is supposed that the number of nodules of ectopic splenic tissue that develop in the peritoneal cavity correlates with the severity of splenic injury. Another mechanism of splenic tissue transplantation is splenic vein emboli or hematogenous spread of splenic pulp, which is suggested by cases of intrahepatic and intracranial splenosis (13,14). One theory suggests that splenic erythrocytic progenitor cells enter the liver via the portal vein, and then grow in response to tissue hypoxia (15).…”
Section: Discussionmentioning
confidence: 99%
“…Another mechanism of splenic tissue transplantation is splenic vein emboli or hematogenous spread of splenic pulp, which is suggested by cases of intrahepatic and intracranial splenosis (5,(12)(13)(14). One theory suggests that splenic erythrocytic progenitor cells enter the liver via the portal vein, and then grow in response to tissue hypoxia (15).…”
Section: Discussionmentioning
confidence: 99%