A Unique Case of Eosinophilic Pancreatitis and Anencephaly in the Fetus of a Type I Diabetic Mother

George, Elias R.; Patel, Shirali S.; Sen, Priyanka; Süle, Norbert

doi:10.4021/gr332w

Cited by 5 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two cases of EP were fetuses of a Type I Diabetic mother [37,38], in which autopsy reports showed a different pattern of pancreatic eosinophilic infiltration; it appears that in these two cases eosinophils either surrounded or infiltrated the pancreatic islets of Langerhans, while the exocrine pancreas was relatively spared.…”

Section: Patients With Eosinophilic Pancreatitismentioning

confidence: 93%

Eosinophilic pancreatitis versus pancreatitis associated with eosinophilic gastroenteritis – a systematic review regarding clinical features and diagnosis

Pinte

Băicuș

2019

Romanian Journal of Internal Medicine

View full text Add to dashboard Cite

Background. Over the past years, eosinophil infiltration involving the gastrointestinal tract and pancreas leading to eosinophilic pancreatitis, eosinophilic gastroenteritis and hypereosinophilic syndrome has been reported in the literature. We aimed to analyze and compare the features involving patients with eosinophilic pancreatitis and pancreatitis associated with eosinophilic gastroenteritis and to determine if there is a connection between the two disorders or if they in fact meet the diagnostic criteria for hypereosinophilic syndrome. Material and methods. The following search was performed in March 2019 on PubMed (MEDLINE) database using the medical terms “pancreatitis”, “eosinophilic pancreatitis”, “eosinophilic gastroenteritis” and “hypereosinophilic syndrome”. Results. The search revealed 119 publications from 1970 onwards. A total of 83 papers were excluded, and the remaining 36 publications, consisting in case reports and case series, were analyzed. From 45 patients, 20 subjects with eosinophilic gastroenteritis developed pancreatitis, 20/45 had eosinophilic pancreatitis, and 5/45 hypereosinophilic syndrome involving the pancreas. There was no significant difference regarding clinical, laboratory and imaging features between the three groups, despite the multiple theories that explain the association of pancreatic and gastrointestinal eosinophilic infiltration. Although there was a strong resemblance between the three groups, histological evidence of eosinophilic gastrointestinal infiltration guided the treatment towards a less invasive way, while subjects with eosinophilic pancreatitis underwent pancreatic surgery to exclude potentially malignant lesions. Conclusion. Although there are various theories that explain pancreatitis development in patients with eosinophilic gastroenteritis, hypereosinophilia diagnostic work-up should be taken into account in all patients with high number of blood eosinophils, even in those with eosinophilic pancreatitis in order to establish the diagnosis using a minimally invasive approach and to apply an adequate treatment.

show abstract

Section: Patients With Eosinophilic Pancreatitismentioning

confidence: 93%

Eosinophilic pancreatitis versus pancreatitis associated with eosinophilic gastroenteritis – a systematic review regarding clinical features and diagnosis

Pinte

Băicuș

2019

Romanian Journal of Internal Medicine

View full text Add to dashboard Cite

show abstract

“…Furthermore, eosinophils in the pancreas were also reported in the 34-week-old fetus of a type I diabetic mother. The pancreas of the foetus was grossly unremarkable, and histological inspection demonstrated an eosinophilic infiltrate in the fibrous septae and islets of Langerhans along with hypertrophy and hyperplasia of the pancreatic islets [46], which was mechanistically reported to the formation of maternal IgG autoantibodies against insulin.…”

Section: Eosinophilic Pancreatitis In the Infants Of Diabetic Mothersmentioning

confidence: 98%

“…Eosinophilic pancreatitis is reported even in infants born from diabetic mothers [44][45][46]. EP was reported in the newly born infant of a diabetic mother for the first time in 1965 [45].…”

Section: Eosinophilic Pancreatitis In the Infants Of Diabetic Mothersmentioning

confidence: 99%

Eosinophilic pancreatitis: a rare or unexplored disease entity?

Manohar

Verma

Singh

et al. 2020

View full text Add to dashboard Cite

Several case reports show accumulation of eosinophils in pancreatitis patients and term the disease as "eosinophilic pancreatitis (EP)". EP usually presents with a pancreatic tumour and abdominal pain in obstructive jaundice, which is generally not diagnosed until the patient undergoes pancreatic resection. Histologically, EP reveals distinct patterns like diffused, periductal, acinar, and septal inflammatory infiltrates with eosinophils, eosinophilic phlebitis, and localised extreme eosinophilic infiltrates related with pseudocyst formation. EP patients also have elevated serum IgE levels with high eosinophil counts in the pancreas as well as in other organs such as the gastrointestinal tract, which is termed as eosinophilic gastroenteritis. Due to the lack of knowledge based on just a few case reports, it is considered that eosinophilic infiltration is quite rare in the pancreas; therefore, the significance of eosinophils in pancreatitis is not yet established. This review assesses the current understanding of eosinophilic pancreatitis and the important role of eosinophils in promoting pancreatic fibrosis including malignancy.

show abstract