A unique case of inflammatory fibroid polyp in the duodenum of a female adolescent

Calderon, Mauricio Giusti; Caivano, Valéria Campos; Junior, Sauro Bagnaresi; Lira, José Ozório de Oliveira; Raimundo, Rodrigo Daminello; Abreu, Luíz Carlos de; Corrêa, João Antônio

doi:10.1097/md.0000000000006131

Cited by 12 publications

(9 citation statements)

References 23 publications

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“…In our case, the history of trauma, tuberculosis, Crohn's disease and sarcoidosis was not recognized. Because Helicobacter pylori (H. pylori) was detected on the surface of gastric epithelium by Giemsa staining using the surgical materials, the association with IFP and H. pylori infection was not excluded [13]. Familial aggregation was reported previously, but it was not noted in our case [14].…”

Section: Conclusion and Discussionmentioning

confidence: 75%

Rare case of gastric inflammatory fibroid polyp located at the fornix of the stomach and mimicking gastric cancer: a case report

et al. 2020

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Background Gastric inflammatory fibroid polyp (IFP) is a rare polypoid lesion of the stomach that is characterized pathologically by the presence of spindle cells, a prominent network of blood vessels, and inflammatory infiltration of eosinophils. IFP is mainly located in the gastric antrum and is usually semi-pedunculated and covered with normal mucosa. There have been several reports of large IFPs with ulceration on the surface, at the apex, but no report of the IFP with ulceration at the fornix of the stomach. We report a case of IFP with ulceration that was suggested to be gastric cancer and was resected for diagnostic treatment. Case presentation A 79-year-old woman presented to our hospital. During mass screening for cancer, stomach fluoroscopy revealed an abnormal shadow. Endoscopy showed an ulcerated tumor at the fornix of stomach; hence, gastric cancer was suggested because of the polypoid lesion with irregular ridges and ulceration. Pathological diagnosis of gastric biopsy specimens revealed an inflammation of the gastric mucosa, and specific findings for gastric cancer were not obtained. Because we could not exclude gastric malignancies such as cancer or gastrointestinal stromal tumor, we performed a partial resection of the stomach with a 2-cm margin using the laparoscopic-assisted method. Pathological examination of the resected specimen revealed that the tumor was present in the submucosal layer and consisted of collagen fiber containing inflammatory cell infiltration of mainly eosinophils. A prominent network of blood vessels was also found in the specimens. Immunohistochemical staining revealed mild positivity for CD34, and α-SMA and was negative for c-kit, DOG-1, s-100, desmin, ALK, and IgG4. The lesion was thus diagnosed as an IFP. The postoperative course was uneventful. The patient is currently asymptomatic and has shown no recurrence. Conclusion IFPs have variable locational, morphological, histological, pathological, and immunohistochemical features. We reported that the gastric IFP was located at the fornix of the stomach and was similar in morphology to gastric cancer. This case is clinically significant to avoid over-surgery.

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Section: Conclusion and Discussionmentioning

confidence: 75%

Rare case of gastric inflammatory fibroid polyp located at the fornix of the stomach and mimicking gastric cancer: a case report

et al. 2020

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“…IFP may occur throughout the GI tract, with the stomach being most commonly involved in adults (66–75%), followed by the small intestine (18–23%), mainly ileum, colon and rectum (4–7%), gallbladder (0.2–1%), oesophagus (1%), duodenum (1%) and appendix (<1%) 2–4 . In children, the distribution seems to be slightly different as most cases are reported in the ileum (7 cases – 35%), followed by stomach, duodenum, colon (2 cases each – 10%) and last jejunum and colon (1 patient per site) 13–27 . This difference should be evaluated carefully, taking into consideration the limited number of cases.…”

Section: Results – Discussionmentioning

confidence: 99%

Inflammatory fibroid polyp of the anus in a 12‐month‐old girl: Case report and review of the literature

Kourti

Dimopoulou

Zavras

et al. 2022

J Paediatrics Child Health

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Inflammatory fibroid polyp (IFP) is a rare, usually solitary and intraluminal polypoid benign tumour that can affect any part of the gastrointestinal (GI) tract. Its aetiology is unknown and clinical presentation depends on the site of involvement. We present the case of a 12‐month‐old girl with IFP and review all reported cases of IFP in children and adolescents <18 years. A 12‐month‐old girl presented with rectal bleeding. The patient underwent colonoscopy which revealed an anus polyp. Surgical resection was performed and histopathological examination of the specimen showed features of IFP. A literature review of 20 cases (including ours) between 1966 and January 2022 is also presented. To our knowledge, this is the youngest reported patient with IFP and the first in the anal area.

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“…During analysis it was found that patients were aged from 4 to 75 years (average 45.2) and the majority of reported patients were female (59.7%). The most common localization of IFPs in small intestine was the ileum (77.9% cases) , followed by the jejunum (13%) [34,[48][49][50][51][52][53][54][55] and the duodenum (6.5%) [46,[56][57][58][59]. In 2.6% cases IFP was found in the ileal pouch [60,61].…”

Section: Resultsmentioning

confidence: 99%

Inflammatory Fibroid Polyp of the Small Intestine: A Case Report and Systematic Literature Review

Ivaniš¹,

Tomas

Vranić

et al. 2020

JGLD

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Aim: Starting from a case presentation, this review aims to present literature data on inflammatory fibroid polyps (IFPs) of the small intestine. Methods: Case report and systematic review. A comprehensive systematic review of English literature using PubMed was conducted, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The used key words were: “inflammatory fibroid polyp” or “Vanek”, including only cases with IFPs localized of the small intestine, published from 1976 to 2019. Results: We present a case of a 38-year old patient with intestinal IFP presenting with acute abdomen due to intussusception diagnosed with ultrasound (US) based on a target sign and visible solid tumor in the small intestine leading to prompt surgical treatment. A diagnosis of IFP was made based on the pathohistological findings. Moreover, a systematic review of small intestine IFPs was conducted which is, to our knowledge, the first comprehensive systematic literature review on this topic. The analysis included 53 case reports or case series concerning 77 cases of small bowel IFPs. The patients were aged from 4 to 75 years (average 45.2), with a female predominance (59.7%). The most common localization was the ileum in 77.9% cases, followed by the jejunum (13%) and the duodenum (6.5%). The most common clinical presentation was abdominal pain due to intussusception (63.6%). Regarding diagnostic methods, computed tomography (CT) was frequently used as primary diagnostic method (26%) followed by exploratory laparotomy (16.9%), endoscopy (7.8%) and US (6.5%). Combination of US and CT contributed to the diagnosis in 9.1% of cases. The majority of cases were treated surgically (92.21%), while only a minority benefited of minimally invasive techniques such as endoscopy. Conclusions: Small bowel IFPs, ones of the least common benign tumors, are characterized by variable clinical signs and symptoms and can potentially lead to serious consequences for the patient.

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A unique case of inflammatory fibroid polyp in the duodenum of a female adolescent

Cited by 12 publications

References 23 publications

Rare case of gastric inflammatory fibroid polyp located at the fornix of the stomach and mimicking gastric cancer: a case report

Rare case of gastric inflammatory fibroid polyp located at the fornix of the stomach and mimicking gastric cancer: a case report

Inflammatory fibroid polyp of the anus in a 12‐month‐old girl: Case report and review of the literature

Inflammatory Fibroid Polyp of the Small Intestine: A Case Report and Systematic Literature Review

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