A Unique Fibrillar Coat on the Surface of Migrating Human Primordial Germ Cells.

An Overview of Clinico-Pathological Correlates of CNS Germinoma

“…Neuroendocrine function surge of reproduction in the diencephalon may also be a contributing factor or a cause of CNS GCTs development, as demonstrated by the location of these tumors and their predominance in the pubertal age group [11,12,13].…”

Intracranial Germ Cell Tumors: A Comprehensive Review of Proposed Embryologic Derivation

“…Moreover, the process of migration involves active changes in the cell membrane and cyto plasmic proteins which affect the cell's interaction with its environment. The adhesiveness of mouse PGCs to fibronectin and laminin decreases during stages of migration to the genital ridges [62,64], A unique fibrillar coat, which potentially can interact with extracellular matrix molecules, has also been identified on the surface of human PGCs during their migration through the mesen chyme of the dorsal mesentery [57], The expression of a surface carbohydrate antigen which may be involved in cellular adhesion is limited to the migration period of mouse PGCs [65] In addition to extracellular matrix molecules, chemotropic factors have been implicated in the migration of a variety of different cell types. Similar mechanisms may be operative in PGCs.…”

Structural bases of the ovarian function: An introduction

“…Many ''hot topics'' are under active investigation today using a morphological approach, especially at microscopic level, that is providing important insights into the structural basis of ovarian physiopathology. Indeed, (a) how oocyte precursors colonize the ovarian tissue during embryonic life (Pereda and Motta, 1991); (b) the process of oogonia differentiation (Sathananthan et al, 2000); (c) the construction of the cell machinery of the mature oocyte and of its surrounding unique extracellular matrix compounds (Cecconi, 2002;Familiari et al, 1992); (d) the establishment of the physical and functional interrelationships between oocyte and somatic elements (Motta et al, 1994;Yokoo and Sato, 2004); (e) the development, differentiation, rearrangement, and interactions of somatic cells forming the ovarian follicles (Tajima et al, 2002); (f) the expression of the thecal capillary neoformation, self-regulated by the ''stop and go'' of a unique angiogenetic process (Macchiarelli, 2000); (g) the morphodynamic and pathophysiology of the epithelium investing ovarian surface (Okamura and Katabuchi, 2005); (h) the competence of the immune system in regulating the ovarian function and the expression of cancer (Bukovsky et al, 1995); (i) the fine tuning of local hemodynamic in ovarian subcompartments and the selection of the dominant follicle (Hunter et al, 2000); (j) the morphological expression of granulosa cells in in-vitro models (Fabbri et al, 2000;Nottola et al, 1991) are a research topic, in many research fields, that deserve a special approach using a morphofunctional point of view. The ovary, in fact, is characterized by great functional plasticity that is necessary to maintain its reproductive competence.…”